Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pHi), which is modulated by a...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Garciarena, C, Malik, A, Swietach, P, Moreno, A, Vaughan-Jones, R
Formatua:	Journal article
Argitaratua:	Federation of American Society of Experimental Biology 2018

Antzeko izenburuak

Low and High pH Gating of Connexin43 Channels
nork: Garciarena, C, et al.
Argitaratua: (2013)

H⁺-activated Na⁺ influx in the ventricular myocyte couples Ca²⁺-signalling to intracellular pH.
nork: Garciarena, C, et al.
Argitaratua: (2013)

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
nork: Garciarena, C, et al.
Argitaratua: (2013)

Gating of cardiac gap junctional channels at acid and alkaline pH
nork: Swietach, P, et al.
Argitaratua: (2005)

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.
nork: Garciarena, C, et al.
Argitaratua: (2013)

Modulation of connexin channel gating by intracellular alkalosis
nork: Zhuang, N, et al.
Argitaratua: (2007)

Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
nork: P. Yahuaca, et al.
Argitaratua: (2000-04-01)

Connexin43 hemichannel-mediated regulation of connexin43.
nork: Kai Li, et al.
Argitaratua: (2013-01-01)

Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes
nork: Rebecca M. Irwin, et al.
Argitaratua: (2024-10-01)

Post-transcriptional regulation of connexin43 in H-Ras-transformed cells.
nork: Mustapha Kandouz, et al.
Argitaratua: (2013-01-01)

Tonabersat enhances temozolomide‐mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition
nork: Elena N. C. Schmidt, et al.
Argitaratua: (2025-03-01)

Human Marrow Stromal Cells Enhance Connexin43 Gap Junction Intercellular Communication in Cultured Astrocytes
nork: Qi Gao, et al.
Argitaratua: (2005-02-01)

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication
nork: Amos Fumagalli, et al.
Argitaratua: (2020-09-01)

Intracellular pH regulation in heart.
nork: Vaughan-Jones, R, et al.
Argitaratua: (2009)

Spatial regulation of intracellular pH in the ventricular myocyte.
nork: Swietach, P, et al.
Argitaratua: (2005)

Betacellulin regulates gap junction intercellular communication by inducing the phosphorylation of connexin 43 in human granulosa-lutein cells
nork: Yuxi Li, et al.
Argitaratua: (2023-05-01)

Plasmalogens Regulate Retinal Connexin 43 Expression and Müller Glial Cells Gap Junction Intercellular Communication and Migration
nork: Rémi Karadayi, et al.
Argitaratua: (2022-03-01)

Coculture of Embryonic Ventricular Myocytes and Mouse Embryonic Stem Cell Enhance Intercellular Signaling by Upregulation of Connexin43
nork: Hui Li, et al.
Argitaratua: (2013-07-01)

hESC expansion and stemness are independent of connexin forty-three-mediated intercellular communication between hESCs and hASC feeder cells.
nork: Jin-Su Kim, et al.
Argitaratua: (2013-01-01)

The chemistry, physiology and pathology of pH in cancer.
nork: Swietach, P, et al.
Argitaratua: (2014)

Spatial aspects of intracellular pH regulation in heart muscle.
nork: Vaughan-Jones, R, et al.
Argitaratua: (2006)

Regulation of tumor pH and the role of carbonic anhydrase 9.
nork: Swietach, P, et al.
Argitaratua: (2007)

ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer
nork: Chen Ni, et al.
Argitaratua: (2022-10-01)

pH-Dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound.
nork: Swietach, P, et al.
Argitaratua: (2007)

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1
nork: Richards, M, et al.
Argitaratua: (2019)

The relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes
nork: Swietach, P, et al.
Argitaratua: (2005)

Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.
nork: Swietach, P, et al.
Argitaratua: (2005)

Modulation of connexin 43 in viral infections
nork: Harry Scott, et al.
Argitaratua: (2024-12-01)

The Role of Connexin 43 in Lung Disease
nork: Julie A. Swartzendruber, et al.
Argitaratua: (2020-12-01)

Interactive mechanism between connexin43 and Cd-induced autophagic flux blockage and gap junctional intercellular communication dysfunction in rat hepatocytes
nork: Yuntian Duan, et al.
Argitaratua: (2023-10-01)

H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.
nork: Swietach, P, et al.
Argitaratua: (2007)

Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications
nork: Tatiana Zubareva, et al.
Argitaratua: (2024-11-01)

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
nork: Lilia Leisle, et al.
Argitaratua: (2020-04-01)

Connexin-43 channels are a novel pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
nork: Dovmark, T, et al.
Argitaratua: (2017)

Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread.
nork: Alexander Tishchenko, et al.
Argitaratua: (2025-01-01)

Author Correction: ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer
nork: Chen Ni, et al.
Argitaratua: (2023-02-01)

Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes.
nork: Swietach, P, et al.
Argitaratua: (2005)

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
nork: Hulikova, A, et al.
Argitaratua: (2013)

Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions
nork: Lina Rimkute, et al.
Argitaratua: (2018-04-01)

Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
nork: Hossein Mostafavi, et al.
Argitaratua: (2014-02-01)