Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pHi), which is modulated by a...

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Detalles Bibliográficos
Main Authors:	Garciarena, C, Malik, A, Swietach, P, Moreno, A, Vaughan-Jones, R
Formato:	Journal article
Publicado:	Federation of American Society of Experimental Biology 2018

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