The oxidation of polychlorinated benzenes by genetically engineered cytochrome P450(cam): potential applications in bioremediation

Polychlorinated aromatic compounds are persistent environmental contaminants; we describe here the redesign and engineering of the haem monooxygenase cytochrome P450(cam) to oxidise these compounds efficiently to the chlorinated phenols which are readily degraded by many micro-organisms, thus provid...

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Những tác giả chính: Jones, J, O'Hare, E, Wong, L
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2000
Miêu tả
Tóm tắt:Polychlorinated aromatic compounds are persistent environmental contaminants; we describe here the redesign and engineering of the haem monooxygenase cytochrome P450(cam) to oxidise these compounds efficiently to the chlorinated phenols which are readily degraded by many micro-organisms, thus providing a basis for novel systems for biological clean-up of these inert compounds.