Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex
<p>The kinetically stable heptadentate gadolinium complex Gd.pDO3A (<strong>1.Gd</strong>) demonstrates significant <small><sup>31</sup></small>P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; ade...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2020
|
| _version_ | 1797102407946076160 |
|---|---|
| author | Tear, LR Maguire, ML Tropiano, M Yao, K Farrer, NJ Faulkner, S Schneider, JE |
| author_facet | Tear, LR Maguire, ML Tropiano, M Yao, K Farrer, NJ Faulkner, S Schneider, JE |
| author_sort | Tear, LR |
| collection | OXFORD |
| description | <p>The kinetically stable heptadentate gadolinium complex Gd.pDO3A (<strong>1.Gd</strong>) demonstrates significant <small><sup>31</sup></small>P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate. Gd.pDO3A (<strong>1.Gd</strong>) binds these species in fast exchange, enabling the relaxation of the bulk phosphate species in solution. This gives rise to <small><sup>31</sup></small>P relaxation enhancements up to 250-fold higher than those observed for <small><sup>31</sup></small>P relaxation enhancements with the commercial MRI contrast agent Gd.DOTA (DOTAREM), <strong>2</strong>. Gd.pDO3A-like complexes may have potential applications as <small><sup>31</sup></small>P magnetic resonance contrast agents, since shortening the <em>T</em><small><sub>1</sub></small> relaxation time of phosphate species would reduce the time needed to acquire <small><sup>31</sup></small>P-MR spectra.</p> |
| first_indexed | 2024-03-07T06:05:35Z |
| format | Journal article |
| id | oxford-uuid:edba68fc-aafa-4a8b-8252-108bec891b33 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:05:35Z |
| publishDate | 2020 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:edba68fc-aafa-4a8b-8252-108bec891b332022-03-27T11:27:19ZEnhancing 31P NMR relaxation rates with a kinetically inert gadolinium complexJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:edba68fc-aafa-4a8b-8252-108bec891b33EnglishSymplectic ElementsRoyal Society of Chemistry2020Tear, LRMaguire, MLTropiano, MYao, KFarrer, NJFaulkner, SSchneider, JE<p>The kinetically stable heptadentate gadolinium complex Gd.pDO3A (<strong>1.Gd</strong>) demonstrates significant <small><sup>31</sup></small>P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate. Gd.pDO3A (<strong>1.Gd</strong>) binds these species in fast exchange, enabling the relaxation of the bulk phosphate species in solution. This gives rise to <small><sup>31</sup></small>P relaxation enhancements up to 250-fold higher than those observed for <small><sup>31</sup></small>P relaxation enhancements with the commercial MRI contrast agent Gd.DOTA (DOTAREM), <strong>2</strong>. Gd.pDO3A-like complexes may have potential applications as <small><sup>31</sup></small>P magnetic resonance contrast agents, since shortening the <em>T</em><small><sub>1</sub></small> relaxation time of phosphate species would reduce the time needed to acquire <small><sup>31</sup></small>P-MR spectra.</p> |
| spellingShingle | Tear, LR Maguire, ML Tropiano, M Yao, K Farrer, NJ Faulkner, S Schneider, JE Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex |
| title | Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex |
| title_full | Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex |
| title_fullStr | Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex |
| title_full_unstemmed | Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex |
| title_short | Enhancing 31P NMR relaxation rates with a kinetically inert gadolinium complex |
| title_sort | enhancing 31p nmr relaxation rates with a kinetically inert gadolinium complex |
| work_keys_str_mv | AT tearlr enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex AT maguireml enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex AT tropianom enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex AT yaok enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex AT farrernj enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex AT faulkners enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex AT schneiderje enhancing31pnmrrelaxationrateswithakineticallyinertgadoliniumcomplex |