Transfusion strategies for major haemorrhage in trauma
Trauma is a leading cause of death worldwide in persons under 44 years of age, and uncontrolled haemorrhage is the most common preventable cause of death in this patient group. The transfusion management of trauma haemorrhage is unrecognisable from 20 years ago. Changes in clinical practice have bee...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2018
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| _version_ | 1797102425747750912 |
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| author | Curry, NS Davenport, RD |
| author_facet | Curry, NS Davenport, RD |
| author_sort | Curry, NS |
| collection | OXFORD |
| description | Trauma is a leading cause of death worldwide in persons under 44 years of age, and uncontrolled haemorrhage is the most common preventable cause of death in this patient group. The transfusion management of trauma haemorrhage is unrecognisable from 20 years ago. Changes in clinical practice have been driven primarily by an increased understanding of the pathophysiology of trauma‐induced coagulopathy (TIC), which is associated with poor clinical outcomes, including a 3‐ to 4‐fold increased risk of death. Targeting this coagulopathy alongside changes to surgical and anaesthetic practices (an overarching strategy known as damage control surgery/damage control resuscitation) has led to a significant reduction in mortality rates over the last two decades. This narrative review will discuss the transfusion practices that are currently used for trauma haemorrhage and the evidence that supports these practices. |
| first_indexed | 2024-03-07T06:05:51Z |
| format | Journal article |
| id | oxford-uuid:edceea1f-6a5b-46a9-bb6b-c93e4a3ca398 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:05:51Z |
| publishDate | 2018 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:edceea1f-6a5b-46a9-bb6b-c93e4a3ca3982022-03-27T11:27:57ZTransfusion strategies for major haemorrhage in traumaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:edceea1f-6a5b-46a9-bb6b-c93e4a3ca398EnglishSymplectic ElementsWiley2018Curry, NSDavenport, RDTrauma is a leading cause of death worldwide in persons under 44 years of age, and uncontrolled haemorrhage is the most common preventable cause of death in this patient group. The transfusion management of trauma haemorrhage is unrecognisable from 20 years ago. Changes in clinical practice have been driven primarily by an increased understanding of the pathophysiology of trauma‐induced coagulopathy (TIC), which is associated with poor clinical outcomes, including a 3‐ to 4‐fold increased risk of death. Targeting this coagulopathy alongside changes to surgical and anaesthetic practices (an overarching strategy known as damage control surgery/damage control resuscitation) has led to a significant reduction in mortality rates over the last two decades. This narrative review will discuss the transfusion practices that are currently used for trauma haemorrhage and the evidence that supports these practices. |
| spellingShingle | Curry, NS Davenport, RD Transfusion strategies for major haemorrhage in trauma |
| title | Transfusion strategies for major haemorrhage in trauma |
| title_full | Transfusion strategies for major haemorrhage in trauma |
| title_fullStr | Transfusion strategies for major haemorrhage in trauma |
| title_full_unstemmed | Transfusion strategies for major haemorrhage in trauma |
| title_short | Transfusion strategies for major haemorrhage in trauma |
| title_sort | transfusion strategies for major haemorrhage in trauma |
| work_keys_str_mv | AT curryns transfusionstrategiesformajorhaemorrhageintrauma AT davenportrd transfusionstrategiesformajorhaemorrhageintrauma |