Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein.
Variation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using the polymerase chain reaction. The degree of polymorphism in these epitopes is more extensive than that found in several geograph...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1989
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| _version_ | 1797102436270211072 |
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| author | Lockyer, M Marsh, K Newbold, C |
| author_facet | Lockyer, M Marsh, K Newbold, C |
| author_sort | Lockyer, M |
| collection | OXFORD |
| description | Variation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using the polymerase chain reaction. The degree of polymorphism in these epitopes is more extensive than that found in several geographically diverse laboratory isolates. These findings strongly suggest that it will not be feasible to include all variants in a polyvalent subunit sporozoite vaccine. |
| first_indexed | 2024-03-07T06:06:00Z |
| format | Journal article |
| id | oxford-uuid:edddc62f-95f6-4e5c-9a00-47da17145099 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:06:00Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:edddc62f-95f6-4e5c-9a00-47da171450992022-03-27T11:28:21ZWild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:edddc62f-95f6-4e5c-9a00-47da17145099EnglishSymplectic Elements at Oxford1989Lockyer, MMarsh, KNewbold, CVariation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using the polymerase chain reaction. The degree of polymorphism in these epitopes is more extensive than that found in several geographically diverse laboratory isolates. These findings strongly suggest that it will not be feasible to include all variants in a polyvalent subunit sporozoite vaccine. |
| spellingShingle | Lockyer, M Marsh, K Newbold, C Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. |
| title | Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. |
| title_full | Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. |
| title_fullStr | Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. |
| title_full_unstemmed | Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. |
| title_short | Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. |
| title_sort | wild isolates of plasmodium falciparum show extensive polymorphism in t cell epitopes of the circumsporozoite protein |
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