An evidence-based framework for priority clinical research questions for COVID-19
<p><strong>Background</strong></p> On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, a...
| मुख्य लेखकों: | , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
International Society of Global Health
2020
|
| _version_ | 1826309635247702016 |
|---|---|
| author | Harris, C Carson, G Baillie, JK Horby, P Nair, H |
| author_facet | Harris, C Carson, G Baillie, JK Horby, P Nair, H |
| author_sort | Harris, C |
| collection | OXFORD |
| description | <p><strong>Background</strong></p>
On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.
<p><strong>Methods</strong></p>
Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Studies were grouped thematically according to clinical research questions addressed. In February 2020, available information on COVID19 was reviewed and compared to the results of the SARS-CoV and MERS-CoV systematic review.
<p><strong>Results</strong></p>
From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled.
<p><strong>Conclusions</strong></p>
Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. Data based on internationally standardised protocols will inform clinical practice real-time. |
| first_indexed | 2024-03-07T07:37:10Z |
| format | Journal article |
| id | oxford-uuid:edeadc33-fab1-4d08-9745-a2f28484c1f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:37:10Z |
| publishDate | 2020 |
| publisher | International Society of Global Health |
| record_format | dspace |
| spelling | oxford-uuid:edeadc33-fab1-4d08-9745-a2f28484c1f42023-03-20T09:35:45ZAn evidence-based framework for priority clinical research questions for COVID-19Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:edeadc33-fab1-4d08-9745-a2f28484c1f4EnglishSymplectic ElementsInternational Society of Global Health2020Harris, CCarson, GBaillie, JKHorby, PNair, H<p><strong>Background</strong></p> On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak. <p><strong>Methods</strong></p> Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Studies were grouped thematically according to clinical research questions addressed. In February 2020, available information on COVID19 was reviewed and compared to the results of the SARS-CoV and MERS-CoV systematic review. <p><strong>Results</strong></p> From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled. <p><strong>Conclusions</strong></p> Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. Data based on internationally standardised protocols will inform clinical practice real-time. |
| spellingShingle | Harris, C Carson, G Baillie, JK Horby, P Nair, H An evidence-based framework for priority clinical research questions for COVID-19 |
| title | An evidence-based framework for priority clinical research questions for COVID-19 |
| title_full | An evidence-based framework for priority clinical research questions for COVID-19 |
| title_fullStr | An evidence-based framework for priority clinical research questions for COVID-19 |
| title_full_unstemmed | An evidence-based framework for priority clinical research questions for COVID-19 |
| title_short | An evidence-based framework for priority clinical research questions for COVID-19 |
| title_sort | evidence based framework for priority clinical research questions for covid 19 |
| work_keys_str_mv | AT harrisc anevidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT carsong anevidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT bailliejk anevidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT horbyp anevidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT nairh anevidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT harrisc evidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT carsong evidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT bailliejk evidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT horbyp evidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 AT nairh evidencebasedframeworkforpriorityclinicalresearchquestionsforcovid19 |