Bifunctional iminophosphorane-catalyzed enantioselective nitroalkane addition to unactivated α,β-unsaturated esters

Herein we describe the enantioselective intermolecular conjugate addition of nitroalkanes to unactivated α,β-unsaturated esters, catalyzed by a bifunctional iminophosphorane (BIMP) superbase. The transformation provides the most direct access to pharmaceutically relevant enantioenriched γ-nitroester...

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Manylion Llyfryddiaeth
Prif Awduron: Rozsar, D, Farley, AJM, McLauchlan, I, Shennan, BDA, Yamazaki, K, Dixon, DJ
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Wiley 2023