Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome.
OBJECTIVES: We investigated the effects of weight loss and maintenance with diets that varied with regard to protein content and glycemic index (GI) on metabolic syndrome (MetSyn) status. METHODS: Secondary analyses were performed within the Diet, Obesity and Genes (DiOGenes) study (2006-2008), a ra...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1826303697245700096 |
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| author | Papadaki, A Linardakis, M Plada, M Larsen, T Damsgaard, C Baak, v Jebb, S Pfeiffer, A Martinez, J Handjieva-Darlenska, T Kunešová, M Holst, C Saris, W Astrup, A Kafatos, A |
| author_facet | Papadaki, A Linardakis, M Plada, M Larsen, T Damsgaard, C Baak, v Jebb, S Pfeiffer, A Martinez, J Handjieva-Darlenska, T Kunešová, M Holst, C Saris, W Astrup, A Kafatos, A |
| author_sort | Papadaki, A |
| collection | OXFORD |
| description | OBJECTIVES: We investigated the effects of weight loss and maintenance with diets that varied with regard to protein content and glycemic index (GI) on metabolic syndrome (MetSyn) status. METHODS: Secondary analyses were performed within the Diet, Obesity and Genes (DiOGenes) study (2006-2008), a randomized controlled dietary intervention. Nine hundred and thirty-eight overweight and obese adults from eight European countries entered an 8-wk low-calorie-diet period. Seven hundred and seventy-three adults who lost at least 8% of their body weights were randomized to one of five ad libitum diets for 6 mo: 1) low-protein (LP)/low-GI (LGI); 2) LP/high-GI (HGI); 3) high-protein (HP)/LGI; 4) HP/HGI; and 5) control diet. MetSyn prevalence and a standardized MetSyn score were assessed at baseline, after the low-calorie diet, and after the intervention. RESULTS: Weight loss among participants while on the low-calorie diet significantly reduced MetSyn prevalence (33.9% versus 15.9%; P < 0.001) and MetSyn score (-1.48 versus -4.45; P < 0.001). During weight maintenance, significant changes in MetSyn score were observed between the groups, with the highest increase detected in the LP/HGI group (P = 0.039, partial η(2) = 0.023). Protein, GI, and their interaction did not have isolated effects on study outcomes. CONCLUSIONS: Neither protein nor GI affected MetSyn status in this sample of European overweight and obese adults. However, a diet with a combination of an increased protein-to-carbohydrate ratio with low-GI foods had beneficial effects on MetSyn factors. |
| first_indexed | 2024-03-07T06:06:39Z |
| format | Journal article |
| id | oxford-uuid:ee13820d-aa52-4703-8599-fb04fabc4ea5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:06:39Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:ee13820d-aa52-4703-8599-fb04fabc4ea52022-03-27T11:29:59ZImpact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ee13820d-aa52-4703-8599-fb04fabc4ea5EnglishSymplectic Elements at Oxford2014Papadaki, ALinardakis, MPlada, MLarsen, TDamsgaard, CBaak, vJebb, SPfeiffer, AMartinez, JHandjieva-Darlenska, TKunešová, MHolst, CSaris, WAstrup, AKafatos, AOBJECTIVES: We investigated the effects of weight loss and maintenance with diets that varied with regard to protein content and glycemic index (GI) on metabolic syndrome (MetSyn) status. METHODS: Secondary analyses were performed within the Diet, Obesity and Genes (DiOGenes) study (2006-2008), a randomized controlled dietary intervention. Nine hundred and thirty-eight overweight and obese adults from eight European countries entered an 8-wk low-calorie-diet period. Seven hundred and seventy-three adults who lost at least 8% of their body weights were randomized to one of five ad libitum diets for 6 mo: 1) low-protein (LP)/low-GI (LGI); 2) LP/high-GI (HGI); 3) high-protein (HP)/LGI; 4) HP/HGI; and 5) control diet. MetSyn prevalence and a standardized MetSyn score were assessed at baseline, after the low-calorie diet, and after the intervention. RESULTS: Weight loss among participants while on the low-calorie diet significantly reduced MetSyn prevalence (33.9% versus 15.9%; P < 0.001) and MetSyn score (-1.48 versus -4.45; P < 0.001). During weight maintenance, significant changes in MetSyn score were observed between the groups, with the highest increase detected in the LP/HGI group (P = 0.039, partial η(2) = 0.023). Protein, GI, and their interaction did not have isolated effects on study outcomes. CONCLUSIONS: Neither protein nor GI affected MetSyn status in this sample of European overweight and obese adults. However, a diet with a combination of an increased protein-to-carbohydrate ratio with low-GI foods had beneficial effects on MetSyn factors. |
| spellingShingle | Papadaki, A Linardakis, M Plada, M Larsen, T Damsgaard, C Baak, v Jebb, S Pfeiffer, A Martinez, J Handjieva-Darlenska, T Kunešová, M Holst, C Saris, W Astrup, A Kafatos, A Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. |
| title | Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. |
| title_full | Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. |
| title_fullStr | Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. |
| title_full_unstemmed | Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. |
| title_short | Impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome. |
| title_sort | impact of weight loss and maintenance with ad libitum diets varying in protein and glycemic index content on metabolic syndrome |
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