Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2)
<p><strong>Background:</strong> Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. New therapeutic approa...
Main Authors: | Shen, Y, Arellano-Garcia, C, Manjivar, R, Jewett, E, Dohle, W, Karchugina, S, Chernoff, J, Potter, B, Barald, K |
---|---|
Format: | Journal article |
Published: |
BioMed Central
2019
|
Similar Items
-
3,17β-bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and nonsteroidal sulfamate derivatives inhibit carbonic anhydrase IX: structure–activity optimization for isoform selectivity
by: Andring, J, et al.
Published: (2019) -
Targeted cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the naturally-occurring anti-cancer metabolite 2-methoxyoest-radiol
by: Potter, B, et al.
Published: (2015) -
2-difluoromethoxy-substituted estratriene sulfamates: synthesis, anti-proliferative sar, anti-tubulin activity and steroid sulfatase inhibition
by: Dohle, W, et al.
Published: (2022) -
Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, anti-proliferative and anti-tubulin activity of dichlorobenzyl-based derivatives and a tubulin co-crystal structure
by: Dohle, W, et al.
Published: (2019) -
Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents
by: Zaraei, S-O, et al.
Published: (2024)