Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

The mechanisms regulating memory CD8(+) T cell function and homeostasis during aging are unclear. CD8(+) effector memory T cells that re-express CD45RA increase considerably in older humans and both aging and persistent CMV infection are independent factors in this process. We used MHC class I tetra...

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Bibliographic Details
Main Authors:	Griffiths, S, Riddell, N, Masters, J, Libri, V, Henson, S, Wertheimer, A, Wallace, D, Sims, S, Rivino, L, Larbi, A, Kemeny, D, Nikolich-Zugich, J, Kern, F, Klenerman, P, Emery, VC, Akbar, A
Format:	Journal article
Language:	English
Published:	2013

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