Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

Background Interferon (IFN) signalling pathways, a key element of the innate immune response, contribute to resistance to conventional chemotherapy, radiotherapy, and immunotherapy, and are often deregulated in cancer. The deubiquitylating enzyme USP18 is a major negative regulator of the IFN signal...

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Hlavní autoři: Pinto-Fernandez, A, Salio, M, Partridge, T, Chen, J, Vere, G, Greenwood, H, Olie, CS, Damianou, A, Scott, HC, Pegg, J, Chiarenza, A, Diaz-Saez, L, Smith, P, Gonzalez-Lopez, C, Patel, B, Jones, N, Hammonds, T, Huber, K, Muschel, R, Borrow, P, Cerundolo, V, Kessler, B
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2020

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