Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy.
Human pancreatic growth hormone releasing factor (hpGHRF(1-40] stimulates the release of growth hormone in normal subjects and some patients with growth hormone deficiency. A study comparing the shorter chain amidated analogue hpGHRF(1-29) with an equivalent dose of hpGHRF(1-40) in seven normal subj...
| প্রধান লেখক: | , , , , , , , |
|---|---|
| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
1984
|
| _version_ | 1826303760995975168 |
|---|---|
| author | Grossman, A Lytras, N Savage, M Wass, J Coy, D Rees, L Jones, A Besser, G |
| author_facet | Grossman, A Lytras, N Savage, M Wass, J Coy, D Rees, L Jones, A Besser, G |
| author_sort | Grossman, A |
| collection | OXFORD |
| description | Human pancreatic growth hormone releasing factor (hpGHRF(1-40] stimulates the release of growth hormone in normal subjects and some patients with growth hormone deficiency. A study comparing the shorter chain amidated analogue hpGHRF(1-29) with an equivalent dose of hpGHRF(1-40) in seven normal subjects showed no significant difference in growth hormone response between the two preparations. Six patients with prolactinomas were also tested; these patients had received megavoltage radiotherapy previously but had developed growth hormone deficiency as shown by insulin induced hypoglycaemia. In all six patients 200 micrograms hpGHRF(1-40) or hpGHRF(1-29)NH2 produced an increase in the serum growth hormone concentration. These data suggest that hpGHRF(1-29)NH2 may be useful for testing the readily releasable pool of growth hormone in the pituitary and that cases of hypothalamo-pituitary irradiation resulting in growth hormone deficiency may be due to failure of synthesis or delivery of endogenous GHRF from the hypothalamus to pituitary cells. |
| first_indexed | 2024-03-07T06:07:37Z |
| format | Journal article |
| id | oxford-uuid:ee64d3a6-8a1a-47e8-98af-af0e6ddc830d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:07:37Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:ee64d3a6-8a1a-47e8-98af-af0e6ddc830d2022-03-27T11:32:19ZGrowth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ee64d3a6-8a1a-47e8-98af-af0e6ddc830dEnglishSymplectic Elements at Oxford1984Grossman, ALytras, NSavage, MWass, JCoy, DRees, LJones, ABesser, GHuman pancreatic growth hormone releasing factor (hpGHRF(1-40] stimulates the release of growth hormone in normal subjects and some patients with growth hormone deficiency. A study comparing the shorter chain amidated analogue hpGHRF(1-29) with an equivalent dose of hpGHRF(1-40) in seven normal subjects showed no significant difference in growth hormone response between the two preparations. Six patients with prolactinomas were also tested; these patients had received megavoltage radiotherapy previously but had developed growth hormone deficiency as shown by insulin induced hypoglycaemia. In all six patients 200 micrograms hpGHRF(1-40) or hpGHRF(1-29)NH2 produced an increase in the serum growth hormone concentration. These data suggest that hpGHRF(1-29)NH2 may be useful for testing the readily releasable pool of growth hormone in the pituitary and that cases of hypothalamo-pituitary irradiation resulting in growth hormone deficiency may be due to failure of synthesis or delivery of endogenous GHRF from the hypothalamus to pituitary cells. |
| spellingShingle | Grossman, A Lytras, N Savage, M Wass, J Coy, D Rees, L Jones, A Besser, G Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. |
| title | Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. |
| title_full | Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. |
| title_fullStr | Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. |
| title_full_unstemmed | Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. |
| title_short | Growth hormone releasing factor: comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy. |
| title_sort | growth hormone releasing factor comparison of two analogues and demonstration of hypothalamic defect in growth hormone release after radiotherapy |
| work_keys_str_mv | AT grossmana growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT lytrasn growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT savagem growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT wassj growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT coyd growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT reesl growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT jonesa growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy AT besserg growthhormonereleasingfactorcomparisonoftwoanaloguesanddemonstrationofhypothalamicdefectingrowthhormonereleaseafterradiotherapy |