Ensemble encoding of action speed by striatal fast-spiking interneurons
Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temp...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer
2019
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| _version_ | 1797102559816581120 |
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| author | Roberts, BM White, MG Patton, MH Chen, R Mathur, BN |
| author_facet | Roberts, BM White, MG Patton, MH Chen, R Mathur, BN |
| author_sort | Roberts, BM |
| collection | OXFORD |
| description | Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhibition on downstream striatal projection neurons. While some in vivo single-unit electrophysiological recordings of putative FSIs support coordinated firing, others do not. Moreover, it is unclear as to what aspect of action FSIs encode. To address this, we used in vivo calcium imaging of genetically identified FSIs in freely moving mice and applied machine learning analyses to decipher the relationship between FSI activity and movement. We report that FSIs exhibit ensemble activity that encodes the speed of action sub-components, including ambulation and head movements. These results suggest FSI population dynamics fit within a Hebbian model for ensemble inhibition of striatal output guiding action. |
| first_indexed | 2024-03-07T06:07:38Z |
| format | Journal article |
| id | oxford-uuid:ee65879a-5fba-4df8-9fb0-20da1b449e17 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:07:38Z |
| publishDate | 2019 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:ee65879a-5fba-4df8-9fb0-20da1b449e172022-03-27T11:32:20ZEnsemble encoding of action speed by striatal fast-spiking interneuronsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ee65879a-5fba-4df8-9fb0-20da1b449e17EnglishSymplectic Elements at OxfordSpringer2019Roberts, BMWhite, MGPatton, MHChen, RMathur, BNStriatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhibition on downstream striatal projection neurons. While some in vivo single-unit electrophysiological recordings of putative FSIs support coordinated firing, others do not. Moreover, it is unclear as to what aspect of action FSIs encode. To address this, we used in vivo calcium imaging of genetically identified FSIs in freely moving mice and applied machine learning analyses to decipher the relationship between FSI activity and movement. We report that FSIs exhibit ensemble activity that encodes the speed of action sub-components, including ambulation and head movements. These results suggest FSI population dynamics fit within a Hebbian model for ensemble inhibition of striatal output guiding action. |
| spellingShingle | Roberts, BM White, MG Patton, MH Chen, R Mathur, BN Ensemble encoding of action speed by striatal fast-spiking interneurons |
| title | Ensemble encoding of action speed by striatal fast-spiking interneurons |
| title_full | Ensemble encoding of action speed by striatal fast-spiking interneurons |
| title_fullStr | Ensemble encoding of action speed by striatal fast-spiking interneurons |
| title_full_unstemmed | Ensemble encoding of action speed by striatal fast-spiking interneurons |
| title_short | Ensemble encoding of action speed by striatal fast-spiking interneurons |
| title_sort | ensemble encoding of action speed by striatal fast spiking interneurons |
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