A genetic hazard score to personalize prostate cancer screening, applied to population data

Background Genetic risk stratification may inform decisions of whether—and when—a man should undergo prostate cancer (PCa) screening. We previously validated a polygenic hazard score (PHS), a weighted sum of 54 single-nucleotide polymorphism genotypes, for accurate prediction of age of onset of aggr...

Descripció completa

Dades bibliogràfiques
Autors principals:	Huynh-Le, M-P, Fan, CC, Karunamuni, R, Walsh, EI, Turner, EL, Lane, JA, Martin, RM, Neal, DE, Donovan, JL, Hamdy, FC, Parsons, JK, Eeles, RA, Easton, DF, Kote-Jarai, Z, Olama, AAA, Garcia, SB, Muir, K, Gronberg, H, Wiklund, F, Aly, M, Schleutker, J, Sipeky, C, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Pharoah, P, Pashayan, N, Khaw, K-T, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Brenner, H, Schöttker, B, Holleczek, B, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Clements, JA, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM
Format:	Journal article
Publicat:	Cold Spring Harbor Laboratory 2019

A genetic hazard score to personalize prostate cancer screening, applied to population data

Ítems similars