A genetic hazard score to personalize prostate cancer screening, applied to population data

A genetic hazard score to personalize prostate cancer screening, applied to population data

Background Genetic risk stratification may inform decisions of whether—and when—a man should undergo prostate cancer (PCa) screening. We previously validated a polygenic hazard score (PHS), a weighted sum of 54 single-nucleotide polymorphism genotypes, for accurate prediction of age of onset of aggr...

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Bibliografiske detaljer
Main Authors:	Huynh-Le, M-P, Fan, CC, Karunamuni, R, Walsh, EI, Turner, EL, Lane, JA, Martin, RM, Neal, DE, Donovan, JL, Hamdy, FC, Parsons, JK, Eeles, RA, Easton, DF, Kote-Jarai, Z, Olama, AAA, Garcia, SB, Muir, K, Gronberg, H, Wiklund, F, Aly, M, Schleutker, J, Sipeky, C, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Pharoah, P, Pashayan, N, Khaw, K-T, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Brenner, H, Schöttker, B, Holleczek, B, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Clements, JA, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM
Format:	Journal article
Udgivet:	Cold Spring Harbor Laboratory 2019

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