Moving lentiviral-based gene therapy into a first-in-man CF trial

Moving lentiviral-based gene therapy into a first-in-man CF trial

Xehetasun bibliografikoak
Egile Nagusiak:	Griesenbach, D, Alton, E, Beekman, J, Boyd, A, Chan, M, Davies, J, Davies, L, Davidson, H, Dekkers, F, Gea-Sorli, S, Gill, D, Hasegawa, M, Higgins, T, Hyndman, L, McLachlan, G, Inoue, M, Hyde, S, Moran, C, Meng, C, Paul-Smith, M, Pringle, I, Pytel, K, Rodriguez-Martinez, A, Stevenson, B, Tsugumine, S
Formatua:	Conference item
Hizkuntza:	English
Argitaratua:	Wiley 2015

Antzeko izenburuak

Preparation for a first-in-man lentivirus trial in cystic fibrosis patients
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Production of SIV-F/HN: a new Lentivirus vector for CF gene therapy
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TOXICOLOGY STUDIES IN SUPPORT OF THE UK CF GENE THERAPY CONSORTIUM'S MULTI-DOSE CLINICAL TRIAL
nork: Griesenbach, U, et al.
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Genetic medicines for CF: Hype versus reality
nork: Alton, E, et al.
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Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.
nork: Alton, E, et al.
Argitaratua: (2016)

EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CF: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY"
nork: Davies, J, et al.
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SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CF
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Update on the UK CF Gene Therapy Consortium Multidoes, non-viral, gene therapy trial
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UPDATE ON THE UK CF GENE THERAPY CONSORTIUM MULTIDOSE, NON-VIRAL, GENE THERAPY TRIAL
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UPDATE ON THE UK CF GENE THERAPY CONSORTIUM MULTIDOSE, NON-VIRAL, GENE THERAPY TRIAL
nork: Alton, E, et al.
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EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CYSTIC FIBROSIS: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY''
nork: Davies, J, et al.
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A PHASE 2B DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF NON-VIRAL MEDIATED GENE THERAPY FOR CF
nork: Alton, E, et al.
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Towards a first-in-human trial with a pseudotyped lentivirus
nork: Alton, EW, et al.
Argitaratua: (2020)

OPTIMISATION OF MOLECULAR ASSAYS FOR CLINICAL TRIAL OF GL67A/PDNA DELIVERY TO NOSE AND LUNG OF CF PATIENTS
nork: Sumner-Jones, S, et al.
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Recombinant Sendai virus vector to evaluate vector distribution in a large animal model of lung gene transfer
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DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
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Gene therapy for respiratory diseases; progress and a changing context
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597: Protocol development for mouse toxicology studies using lentiviral gene therapy
nork: Sinadinos, A, et al.
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REPEAT ADMINISTRATION OF GL67A/PGM169 IS FEASIBLE, SAFE, AND PRODUCES ENDOGENOUS LEVELS OF CFTR EXPRESSION AFTER 12 DOSES
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Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung.
nork: Alton, E, et al.
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Cumulative CFTR expression following repeated aerosol delivery of non-viral pGM169/GL67A formulation to mouse lung
nork: Alton, E, et al.
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Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
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Development of lentiviral vector respiratory tract dosing methods in anticipation of rodent GLP toxicology assessment
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The lung as a factory to produce secreted intrapulmonary and circulatory proteins
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EXERCISE CAPACITY AND PHYSICAL ACTIVITY IN PATIENTS WITH CF: DATA FROM THE UK CF GENE THERAPY CONSORTIUM (UKCFGTC) 'RUN-IN' STUDY
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UKCF gene therapy consortium tracking study: Sputum and serum calprotectin are useful novel measurements in CF exacerbation
nork: Gray, R, et al.
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The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins
nork: Paul-Smith, M, et al.
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3-STEP TAQMAN RT-PCR: ULTIMATE MESSENGER RNA DETECTION SENSITIVITY FOR CF GENE THERAPY CLINICAL TRIALS
nork: McCormick, D, et al.
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Pre-existing immunity to human parainfluenza virus (hPIV) does not affect rSIV.F/HN-mediated transduction efficiency
nork: Pytel, K, et al.
Argitaratua: (2016)

SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CYSTIC FIBROSIS
nork: Davies, G, et al.
Argitaratua: (2011)

Assessment of selected media supplements to improve F/HN lentiviral vector production yields
nork: Gélinas, J, et al.
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Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
nork: McLachlan, G, et al.
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Cholesterol as an enhancer of lentiviral vector production in serum-free transient transfection
nork: Gelinas, J, et al.
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LONGITUDINAL ASSESSMENT OF BIOMARKERS FOR CLINICAL TRIALS OF NOVEL THERAPEUTIC AGENTS: THE RUN-IN STUDY
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A method for assessing the distribution of eGFP expressing cells in the mouse lung following lentiviral vector transduction
nork: Munday, R, et al.
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A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis
nork: Alton, E, et al.
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A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis.
nork: Alton, E, et al.
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Large-scale, high-throughput production of lentiviral vectors for multiple disease applications
nork: Ashworth, R, et al.
Argitaratua: (2018)

Recombinant Sendai virus vector to evaluate vector distribution in a large animal model of lung gene transfer
nork: McLachlan, G, et al.
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LONGITUDINAL ASSESSMENT OF BIOMARKERS FOR CLINICAL TRIALS OF NOVEL THERAPEUTIC AGENTS; THE RUN-IN STUDY
nork: Alton, E, et al.
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