HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians.
AIM: To determine the glycosylated haemoglobin (HbA(1c)) cut-points for diabetes and impaired fasting glucose (IFG) among Asian Indians. METHODS: Participants (n=525) were a random sample selected from the India Health Study. Based on history and fasting plasma glucose (FPG), participants were clas...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826303812687626240 |
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| author | Nair, M Prabhakaran, D Narayan, K Sinha, R Lakshmy, R Devasenapathy, N Daniel, C Gupta, R George, P Mathew, A Tandon, N Reddy, K |
| author_facet | Nair, M Prabhakaran, D Narayan, K Sinha, R Lakshmy, R Devasenapathy, N Daniel, C Gupta, R George, P Mathew, A Tandon, N Reddy, K |
| author_sort | Nair, M |
| collection | OXFORD |
| description | AIM: To determine the glycosylated haemoglobin (HbA(1c)) cut-points for diabetes and impaired fasting glucose (IFG) among Asian Indians. METHODS: Participants (n=525) were a random sample selected from the India Health Study. Based on history and fasting plasma glucose (FPG), participants were classified into known diabetes, newly diagnosed diabetes (NDD), impaired fasting glucose (IFG) [ADA and WHO criteria] or normal fasting glucose (NFG). Receiver Operating Characteristic curves were used to identify the optimum sensitivity and specificity for defining HbA(1c) cut-points for NDD and IFG against the FPG criteria. RESULTS: There were 64 participants with a known history of diabetes. Of the remaining 461, IFG was present in 44.7% (ADA) and 18.2% (WHO), and 10.4% were NDD. Mean HbA(1c) were 5.4 (±0.04)% for NFG; 5.7 (±0.06)% among IFG-ADA, 5.8 (±0.09)% among IFG-WHO; 7.5 (±0.33)% for NDD and 8.4 (±0.32)% for known diabetes. Optimal HbA(1c) cut-point for NDD was 5.8% (sensitivity=75%, specificity=75.5%, AUC=0.819). Cut-point for IFG (ADA) was 5.5% (sensitivity=59.7%, specificity=59.9%, AUC=0.628) and for IFG (WHO) was 5.6% (sensitivity=60.7%, specificity=65.1%, AUC=0.671). CONCLUSION: In this study population from north and south regions of India, the HbA(1c) cut-point that defines NDD (≥5.8%) was much lower than that proposed by an international expert committee and the American Diabetes Association (≥6.5%). A cut-point of ≥5.5% or ≥5.6% defined IFG, and was slightly lower than the ≥5.7% for high risk proposed, but accuracy was less than 70%. |
| first_indexed | 2024-03-07T06:08:23Z |
| format | Journal article |
| id | oxford-uuid:ee9e78ef-c499-4e33-9763-a1f838a491c2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:08:23Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:ee9e78ef-c499-4e33-9763-a1f838a491c22022-03-27T11:34:11ZHbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ee9e78ef-c499-4e33-9763-a1f838a491c2EnglishSymplectic Elements at Oxford2011Nair, MPrabhakaran, DNarayan, KSinha, RLakshmy, RDevasenapathy, NDaniel, CGupta, RGeorge, PMathew, ATandon, NReddy, K AIM: To determine the glycosylated haemoglobin (HbA(1c)) cut-points for diabetes and impaired fasting glucose (IFG) among Asian Indians. METHODS: Participants (n=525) were a random sample selected from the India Health Study. Based on history and fasting plasma glucose (FPG), participants were classified into known diabetes, newly diagnosed diabetes (NDD), impaired fasting glucose (IFG) [ADA and WHO criteria] or normal fasting glucose (NFG). Receiver Operating Characteristic curves were used to identify the optimum sensitivity and specificity for defining HbA(1c) cut-points for NDD and IFG against the FPG criteria. RESULTS: There were 64 participants with a known history of diabetes. Of the remaining 461, IFG was present in 44.7% (ADA) and 18.2% (WHO), and 10.4% were NDD. Mean HbA(1c) were 5.4 (±0.04)% for NFG; 5.7 (±0.06)% among IFG-ADA, 5.8 (±0.09)% among IFG-WHO; 7.5 (±0.33)% for NDD and 8.4 (±0.32)% for known diabetes. Optimal HbA(1c) cut-point for NDD was 5.8% (sensitivity=75%, specificity=75.5%, AUC=0.819). Cut-point for IFG (ADA) was 5.5% (sensitivity=59.7%, specificity=59.9%, AUC=0.628) and for IFG (WHO) was 5.6% (sensitivity=60.7%, specificity=65.1%, AUC=0.671). CONCLUSION: In this study population from north and south regions of India, the HbA(1c) cut-point that defines NDD (≥5.8%) was much lower than that proposed by an international expert committee and the American Diabetes Association (≥6.5%). A cut-point of ≥5.5% or ≥5.6% defined IFG, and was slightly lower than the ≥5.7% for high risk proposed, but accuracy was less than 70%. |
| spellingShingle | Nair, M Prabhakaran, D Narayan, K Sinha, R Lakshmy, R Devasenapathy, N Daniel, C Gupta, R George, P Mathew, A Tandon, N Reddy, K HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. |
| title | HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. |
| title_full | HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. |
| title_fullStr | HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. |
| title_full_unstemmed | HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. |
| title_short | HbA(1c) values for defining diabetes and impaired fasting glucose in Asian Indians. |
| title_sort | hba 1c values for defining diabetes and impaired fasting glucose in asian indians |
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