Executive "brake failure" following deactivation of human frontal lobe.
In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been stud...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797102648419155968 |
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| author | Chambers, C Bellgrove, M Stokes, M Henderson, T Garavan, H Robertson, I Morris, A Mattingley, J |
| author_facet | Chambers, C Bellgrove, M Stokes, M Henderson, T Garavan, H Robertson, I Morris, A Mattingley, J |
| author_sort | Chambers, C |
| collection | OXFORD |
| description | In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition. |
| first_indexed | 2024-03-07T06:08:56Z |
| format | Journal article |
| id | oxford-uuid:eecd68d7-1542-40b1-8d7d-5c8482833175 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:08:56Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:eecd68d7-1542-40b1-8d7d-5c84828331752022-03-27T11:35:31ZExecutive "brake failure" following deactivation of human frontal lobe.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eecd68d7-1542-40b1-8d7d-5c8482833175EnglishSymplectic Elements at Oxford2006Chambers, CBellgrove, MStokes, MHenderson, TGaravan, HRobertson, IMorris, AMattingley, JIn the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition. |
| spellingShingle | Chambers, C Bellgrove, M Stokes, M Henderson, T Garavan, H Robertson, I Morris, A Mattingley, J Executive "brake failure" following deactivation of human frontal lobe. |
| title | Executive "brake failure" following deactivation of human frontal lobe. |
| title_full | Executive "brake failure" following deactivation of human frontal lobe. |
| title_fullStr | Executive "brake failure" following deactivation of human frontal lobe. |
| title_full_unstemmed | Executive "brake failure" following deactivation of human frontal lobe. |
| title_short | Executive "brake failure" following deactivation of human frontal lobe. |
| title_sort | executive brake failure following deactivation of human frontal lobe |
| work_keys_str_mv | AT chambersc executivebrakefailurefollowingdeactivationofhumanfrontallobe AT bellgrovem executivebrakefailurefollowingdeactivationofhumanfrontallobe AT stokesm executivebrakefailurefollowingdeactivationofhumanfrontallobe AT hendersont executivebrakefailurefollowingdeactivationofhumanfrontallobe AT garavanh executivebrakefailurefollowingdeactivationofhumanfrontallobe AT robertsoni executivebrakefailurefollowingdeactivationofhumanfrontallobe AT morrisa executivebrakefailurefollowingdeactivationofhumanfrontallobe AT mattingleyj executivebrakefailurefollowingdeactivationofhumanfrontallobe |