Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.
BACKGROUND: Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use. AIM: To restore serum Mg(2+) concentrations in PPI-i...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2016
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| _version_ | 1826303855798779904 |
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| author | Hess, M de Baaij, J Broekman, M Bisseling, T Haarhuis, B Tan, A Morsche, R Hoenderop, J Bindels, R Drenth, J |
| author_facet | Hess, M de Baaij, J Broekman, M Bisseling, T Haarhuis, B Tan, A Morsche, R Hoenderop, J Bindels, R Drenth, J |
| author_sort | Hess, M |
| collection | OXFORD |
| description | BACKGROUND: Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use. AIM: To restore serum Mg(2+) concentrations in PPI-induced hypomagnesaemia patients by dietary supplementation with inulin fibres. METHODS: Eleven patients with PPI-induced hypomagnesaemia and 10 controls were treated with inulin (20 g/day). Each trial consisted of two cycles of 14-day inulin treatment followed by a washout period of 14 days. Patients continued to use their PPI. Serum Mg(2+) levels served as the primary endpoint. RESULTS: Inulin significantly enhanced serum Mg(2+) levels from 0.60 to 0.68 mmol/L in PPI-induced hypomagnesaemia patients, and from 0.84 to 0.93 mmol/L in controls. As a consequence 24 h urinary Mg(2+) excretion was significantly increased in patients with PPI-induced hypomagnesaemia (0.3-2.2 mmol/day). Symptoms related to hypomagnesaemia, including muscle cramps and paraesthesia, were reduced during intervention with inulin. CONCLUSION: Inulin increases serum Mg(2+) concentrations under PPI maintenance in patients with PPI-induced hypomagnesaemia. |
| first_indexed | 2024-03-07T06:09:02Z |
| format | Journal article |
| id | oxford-uuid:eed5ec20-644a-4797-98d5-5ebcac86e528 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:09:02Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | oxford-uuid:eed5ec20-644a-4797-98d5-5ebcac86e5282022-03-27T11:35:49ZInulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eed5ec20-644a-4797-98d5-5ebcac86e528EnglishSymplectic Elements at Oxford2016Hess, Mde Baaij, JBroekman, MBisseling, THaarhuis, BTan, AMorsche, RHoenderop, JBindels, RDrenth, JBACKGROUND: Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use. AIM: To restore serum Mg(2+) concentrations in PPI-induced hypomagnesaemia patients by dietary supplementation with inulin fibres. METHODS: Eleven patients with PPI-induced hypomagnesaemia and 10 controls were treated with inulin (20 g/day). Each trial consisted of two cycles of 14-day inulin treatment followed by a washout period of 14 days. Patients continued to use their PPI. Serum Mg(2+) levels served as the primary endpoint. RESULTS: Inulin significantly enhanced serum Mg(2+) levels from 0.60 to 0.68 mmol/L in PPI-induced hypomagnesaemia patients, and from 0.84 to 0.93 mmol/L in controls. As a consequence 24 h urinary Mg(2+) excretion was significantly increased in patients with PPI-induced hypomagnesaemia (0.3-2.2 mmol/day). Symptoms related to hypomagnesaemia, including muscle cramps and paraesthesia, were reduced during intervention with inulin. CONCLUSION: Inulin increases serum Mg(2+) concentrations under PPI maintenance in patients with PPI-induced hypomagnesaemia. |
| spellingShingle | Hess, M de Baaij, J Broekman, M Bisseling, T Haarhuis, B Tan, A Morsche, R Hoenderop, J Bindels, R Drenth, J Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia. |
| title | Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia. |
| title_full | Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia. |
| title_fullStr | Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia. |
| title_full_unstemmed | Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia. |
| title_short | Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia. |
| title_sort | inulin significantly improves serum magnesium levels in proton pump inhibitor induced hypomagnesaemia |
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