The adenosine A2B receptor drives osteoclast-mediated bone resorption in hypoxic microenvironments
Osteoclast-mediated bone destruction is amplified in the hypoxic synovial microenvironment of rheumatoid arthritis (RA). This increased bone resorption is driven by the hypoxia-inducible transcription factor HIF. We identified hypoxic induction of the HIF-regulated adenosine A2B receptor in primary...
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| Format: | Journal article |
| Language: | English |
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MDPI
2019
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