The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens.
OBJECTIVES: This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition. METHODS: We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standardise...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797102710283042816 |
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| author | Sheehy, S Atkins, B Bejon, P Byren, I Wyllie, D Athanasou, N Berendt, A McNally, M |
| author_facet | Sheehy, S Atkins, B Bejon, P Byren, I Wyllie, D Athanasou, N Berendt, A McNally, M |
| author_sort | Sheehy, S |
| collection | OXFORD |
| description | OBJECTIVES: This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition. METHODS: We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standardised surgical sampling protocol was used. RESULTS: Staphylococcus aureus was most commonly isolated (32%) amongst a wide range of organisms including gram negative bacilli, anaerobes and coagulase negative staphylococci. Low grade pathogens were not confined to patients with a history of metalwork, a high proportion of cases were polymicrobial (29%) and culture negative cases were common (28%). No clear predictors of causative organism could be established. Many isolates were found to be resistant to commonly used empirical anti-microbial regimens. CONCLUSIONS: The wide range of causative organisms and degree of resistance to commonly used anti-microbials supports the importance of extensive intra-operative sampling and provides important information to guide clinicians' choice of empirical antibiotics. |
| first_indexed | 2024-03-07T06:09:39Z |
| format | Journal article |
| id | oxford-uuid:ef06f442-f599-43ab-bf92-ec9b6f423d2f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:09:39Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:ef06f442-f599-43ab-bf92-ec9b6f423d2f2022-03-27T11:37:20ZThe microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef06f442-f599-43ab-bf92-ec9b6f423d2fEnglishSymplectic Elements at Oxford2010Sheehy, SAtkins, BBejon, PByren, IWyllie, DAthanasou, NBerendt, AMcNally, M OBJECTIVES: This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition. METHODS: We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standardised surgical sampling protocol was used. RESULTS: Staphylococcus aureus was most commonly isolated (32%) amongst a wide range of organisms including gram negative bacilli, anaerobes and coagulase negative staphylococci. Low grade pathogens were not confined to patients with a history of metalwork, a high proportion of cases were polymicrobial (29%) and culture negative cases were common (28%). No clear predictors of causative organism could be established. Many isolates were found to be resistant to commonly used empirical anti-microbial regimens. CONCLUSIONS: The wide range of causative organisms and degree of resistance to commonly used anti-microbials supports the importance of extensive intra-operative sampling and provides important information to guide clinicians' choice of empirical antibiotics. |
| spellingShingle | Sheehy, S Atkins, B Bejon, P Byren, I Wyllie, D Athanasou, N Berendt, A McNally, M The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. |
| title | The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. |
| title_full | The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. |
| title_fullStr | The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. |
| title_full_unstemmed | The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. |
| title_short | The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. |
| title_sort | microbiology of chronic osteomyelitis prevalence of resistance to common empirical anti microbial regimens |
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