Empagliflozin rescues pro-arrhythmic and Ca 2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Empagliflozin rescues pro-arrhythmic and Ca 2+ homeostatic effects of transverse aortic constriction in intact murine hearts

We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge resulted in reduced late Na+ currents, and increased phosphory...

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Détails bibliographiques
Auteurs principaux: Wen, Q, Zhang, R, Ye, K, Yang, J, Shi, H, Liu, Z, Li, Y, Liu, T, Zhang, S, Chen, W, Wu, J, Liu, W, Tan, X, Lei, M, Huang, CL, Ou, X
Format: Journal article
Langue:English
Publié: Nature Research 2024

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