Empagliflozin rescues pro-arrhythmic and Ca 2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Empagliflozin rescues pro-arrhythmic and Ca 2+ homeostatic effects of transverse aortic constriction in intact murine hearts

We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge resulted in reduced late Na+ currents, and increased phosphory...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Wen, Q, Zhang, R, Ye, K, Yang, J, Shi, H, Liu, Z, Li, Y, Liu, T, Zhang, S, Chen, W, Wu, J, Liu, W, Tan, X, Lei, M, Huang, CL, Ou, X
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Nature Research 2024

Antzeko izenburuak

Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts
nork: Qiang Wen, et al.
Argitaratua: (2024-07-01)

Identification of Transcriptional Variation in Aortic Remodeling Using a Murine Transverse Aortic Constriction (TAC) Model
nork: Xinlu Zhang, et al.
Argitaratua: (2020-11-01)

Mildly Increased Renin Expression in the Absence of Kidney Injury in the Murine Transverse Aortic Constriction Model
nork: Marian Wesseling, et al.
Argitaratua: (2021-06-01)

Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model.
nork: Sundaravadivel Balasubramanian, et al.
Argitaratua: (2015-01-01)

Identification of Ferroptosis-Related Genes in Heart Failure Induced by Transverse Aortic Constriction
nork: Gu JJ, et al.
Argitaratua: (2023-10-01)

In silico investigation of pro-arrhythmic effects of azithromycin on the human ventricle
nork: Yizhou Liu, et al.
Argitaratua: (2021-09-01)

In silico investigations into human ventricular pro-arrhythmic mechanisms combined with in vivo and in vitro experiments
nork: Zhou, X
Argitaratua: (2016)

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.
nork: Passini, E, et al.
Argitaratua: (2015)

Establishment of a Rabbit Heart-failure Model Using Transverse Aortic Constriction
nork: LUO Qingyi, et al.
Argitaratua: (2022-10-01)

HOMEOSTATIC SYNAPTIC PLASTICITY RESCUES NEURAL CODING RELIABILITY
nork: Eyal Rozenfeld, et al.
Argitaratua: (2023-10-01)

Homeostatic synaptic plasticity rescues neural coding reliability
nork: Eyal Rozenfeld, et al.
Argitaratua: (2023-05-01)

Empagliflozin: Novel antidiabetes and pro-cardiac drug
nork: Monish S Raut, et al.
Argitaratua: (2017-01-01)

Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling
nork: Xu Chen, et al.
Argitaratua: (2022-12-01)

Application of cardiac electrophysiology simulations to pro−arrhythmic safety testing
nork: Mirams, G, et al.
Argitaratua: (2012)

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.
nork: Mirams, G, et al.
Argitaratua: (2012)

Machine Learning Identification of Pro-arrhythmic Structures in Cardiac Fibrosis
nork: Radek Halfar, et al.
Argitaratua: (2021-08-01)

Surgical models of hypertrophy and heart failure: Myocardial infarction and transverse aortic constriction
nork: Lygate, C
Argitaratua: (2006)

Modified Protocol for A Mouse Heart Failure Model Using Minimally Invasive Transverse Aortic Constriction
nork: Bilin Liu, et al.
Argitaratua: (2020-12-01)

Renal Denervation Attenuates Multi-Organ Fibrosis and Improves Vascular Remodeling in Rats with Transverse Aortic Constriction Induced Cardiomyopathy
nork: Kai Wang, et al.
Argitaratua: (2016-11-01)

Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator
nork: McMillan, B, et al.
Argitaratua: (2017)

Mitral Annular Disjunction: Pathophysiology, Pro-Arrhythmic Profile and Repair Pearls
nork: Dimos Karangelis, et al.
Argitaratua: (2022-03-01)

EZH2 Inhibition Ameliorates Transverse Aortic Constriction-Induced Pulmonary Arterial Hypertension in Mice
nork: Zhan-Li Shi, et al.
Argitaratua: (2018-01-01)

A protocol for transverse cardiac slicing and optical mapping in murine heart
nork: He, S, et al.
Argitaratua: (2019)

Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats.
nork: Nils Thomas Songstad, et al.
Argitaratua: (2014-01-01)

Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction
nork: Yasuharu Shinoda, et al.
Argitaratua: (2016-07-01)

Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation
nork: Nicola Boccella, et al.
Argitaratua: (2021-04-01)

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure
nork: Yongming Li, et al.
Argitaratua: (2017-06-01)

Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways
nork: M. Keshavarz, et al.
Argitaratua: (2018-05-01)

Hypertension Induces Pro-arrhythmic Cardiac Connexome Disorders: Protective Effects of Treatment
nork: Matus Sykora, et al.
Argitaratua: (2023-02-01)

Pro-arrhythmic role of adrenergic spatial densities in the human atria: An in-silico study.
nork: Karl Magtibay, et al.
Argitaratua: (2023-01-01)

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk
nork: Mark R. Davies, et al.
Argitaratua: (2020-08-01)

Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens
nork: Jan Lukas Kleiner, et al.
Argitaratua: (2021-01-01)

Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury
nork: Wang X, et al.
Argitaratua: (2024-12-01)

Inhibition of Uncoupling Protein 2 Attenuates Cardiac Hypertrophy Induced by Transverse Aortic Constriction in Mice
nork: Xiao-Bing Ji, et al.
Argitaratua: (2015-07-01)

Evaluation of the transverse aortic constriction model in ICR and C57BL/6J mice
nork: Mengying Huang, et al.
Argitaratua: (2022-11-01)

ATF3 expression in cardiomyocytes and myofibroblasts following transverse aortic constriction displays distinct phenotypes
nork: Abu-Sharki Soraya, et al.
Argitaratua: (2021-02-01)

Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways
nork: Run-Jing Li, et al.
Argitaratua: (2022-08-01)

Apigenin Attenuates Transverse Aortic Constriction-Induced Myocardial Hypertrophy: The Key Role of miR-185-5p/SREBP2-Mediated Autophagy
nork: Yan N, et al.
Argitaratua: (2024-08-01)

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities
nork: Trovato, C, et al.
Argitaratua: (2020)

Computational framework for multiscale investigation of pro-arrhythmic mechanisms in the human cardiac Purkinje system
nork: Trovato, C
Argitaratua: (2020)