HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study.
BACKGROUND: Different studies have reported an association between HIV infection, antiretroviral therapies, and impaired bone metabolism, but data on their impact on fracture risk are scarce. We studied the association between a clinical diagnosis of HIV infection and fracture risk. METHODS: We cond...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Lippincott Williams and Wilkins
2014
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| _version_ | 1797102739840303104 |
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| author | Prieto-Alhambra, D Güerri-Fernández, R De Vries, F Lalmohamed, A Bazelier, M Starup-Linde, J Diez-Perez, A Cooper, C Vestergaard, P |
| author_facet | Prieto-Alhambra, D Güerri-Fernández, R De Vries, F Lalmohamed, A Bazelier, M Starup-Linde, J Diez-Perez, A Cooper, C Vestergaard, P |
| author_sort | Prieto-Alhambra, D |
| collection | OXFORD |
| description | BACKGROUND: Different studies have reported an association between HIV infection, antiretroviral therapies, and impaired bone metabolism, but data on their impact on fracture risk are scarce. We studied the association between a clinical diagnosis of HIV infection and fracture risk. METHODS: We conducted a case-control study using data from the Danish National Health Service registries, including 124,655 fracture cases and 373,962 age- and gender-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. RESULTS: A total of 50 (0.40/1000) patients in the fracture group and 52 (0.14/1000) controls had an HIV diagnosis. The risk of any fracture was thus significantly increased among HIV-infected patients (age- and gender-matched OR = 2.89, 95% CI: 1.99 to 4.18). Similarly, significant increases in the risk of hip (OR = 8.99, 95% CI: 1.39 to 58.0), forearm (OR = 3.50, 95% CI: 1.26 to 9.72), and spine fractures (OR = 9.00, 95% CI: 1.39 to 58.1) were observed. CONCLUSIONS: HIV infection is associated with an almost 3-fold increase in fracture risk compared with that of age- and gender-matched uninfected patients. HIV patients are also at an almost 9-fold higher risk of hip fracture. |
| first_indexed | 2024-03-07T06:10:05Z |
| format | Journal article |
| id | oxford-uuid:ef2bdea3-7d10-43ad-bbde-8bb219d478b4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:10:05Z |
| publishDate | 2014 |
| publisher | Lippincott Williams and Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:ef2bdea3-7d10-43ad-bbde-8bb219d478b42022-03-27T11:38:24ZHIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef2bdea3-7d10-43ad-bbde-8bb219d478b4EnglishSymplectic Elements at OxfordLippincott Williams and Wilkins2014Prieto-Alhambra, DGüerri-Fernández, RDe Vries, FLalmohamed, ABazelier, MStarup-Linde, JDiez-Perez, ACooper, CVestergaard, PBACKGROUND: Different studies have reported an association between HIV infection, antiretroviral therapies, and impaired bone metabolism, but data on their impact on fracture risk are scarce. We studied the association between a clinical diagnosis of HIV infection and fracture risk. METHODS: We conducted a case-control study using data from the Danish National Health Service registries, including 124,655 fracture cases and 373,962 age- and gender-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. RESULTS: A total of 50 (0.40/1000) patients in the fracture group and 52 (0.14/1000) controls had an HIV diagnosis. The risk of any fracture was thus significantly increased among HIV-infected patients (age- and gender-matched OR = 2.89, 95% CI: 1.99 to 4.18). Similarly, significant increases in the risk of hip (OR = 8.99, 95% CI: 1.39 to 58.0), forearm (OR = 3.50, 95% CI: 1.26 to 9.72), and spine fractures (OR = 9.00, 95% CI: 1.39 to 58.1) were observed. CONCLUSIONS: HIV infection is associated with an almost 3-fold increase in fracture risk compared with that of age- and gender-matched uninfected patients. HIV patients are also at an almost 9-fold higher risk of hip fracture. |
| spellingShingle | Prieto-Alhambra, D Güerri-Fernández, R De Vries, F Lalmohamed, A Bazelier, M Starup-Linde, J Diez-Perez, A Cooper, C Vestergaard, P HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study. |
| title | HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study. |
| title_full | HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study. |
| title_fullStr | HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study. |
| title_full_unstemmed | HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study. |
| title_short | HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study. |
| title_sort | hiv infection and its association with an excess risk of clinical fractures a nationwide case control study |
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