Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.
A set of rat-human and rat-rat chimeric mAb has been created, all possessing V regions identical in their specificity for the mouse CD8 Ag. In vitro all antibodies were able to block cell-mediated lysis but varied greatly in their capacity to utilize rabbit complement. We examined the ability of the...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1992
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