The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways.
We investigate the effects on arterial P(CO(2)) and on arterial-end tidal P(CO(2)) difference of six different ventilation patterns of equal tidal volume, and also of various combinations of tidal volume and respiratory rate that maintain a constant alveolar ventilation. We use predictions from thre...
| Những tác giả chính: | , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2002
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| _version_ | 1826303939518136320 |
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| author | Whiteley, J Turner, M Baker, AB Gavaghan, D Hahn, C |
| author_facet | Whiteley, J Turner, M Baker, AB Gavaghan, D Hahn, C |
| author_sort | Whiteley, J |
| collection | OXFORD |
| description | We investigate the effects on arterial P(CO(2)) and on arterial-end tidal P(CO(2)) difference of six different ventilation patterns of equal tidal volume, and also of various combinations of tidal volume and respiratory rate that maintain a constant alveolar ventilation. We use predictions from three different mathematical models. Models 1 (distributed) and 2 (compartmental) include combined convection and diffusion effects. Model 3 incorporates a single well-mixed alveolar compartment and an anatomical dead-space in which plug flow occurs. We found that: (i) breathing patterns with longer inspiratory times yield lower arterial P(CO(2)); (ii) varying tidal volume and respiratory rate so that alveolar ventilation is kept constant may change both PA(CO(2)) and the PA(CO(2))-PET(CO(2)) difference; (iii) the distributed model predicts higher end-tidal and arterial P(CO(2)) than the compartmental models under similar conditions; and (iv) P(CO(2)) capnograms predicted by the distributed model exhibit longer phase I and steeper phase II than other models. |
| first_indexed | 2024-03-07T06:10:17Z |
| format | Journal article |
| id | oxford-uuid:ef3f99e4-acbf-4548-97b7-48ffd8c00372 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:10:17Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:ef3f99e4-acbf-4548-97b7-48ffd8c003722022-03-27T11:38:55ZThe effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef3f99e4-acbf-4548-97b7-48ffd8c00372EnglishSymplectic Elements at Oxford2002Whiteley, JTurner, MBaker, ABGavaghan, DHahn, CWe investigate the effects on arterial P(CO(2)) and on arterial-end tidal P(CO(2)) difference of six different ventilation patterns of equal tidal volume, and also of various combinations of tidal volume and respiratory rate that maintain a constant alveolar ventilation. We use predictions from three different mathematical models. Models 1 (distributed) and 2 (compartmental) include combined convection and diffusion effects. Model 3 incorporates a single well-mixed alveolar compartment and an anatomical dead-space in which plug flow occurs. We found that: (i) breathing patterns with longer inspiratory times yield lower arterial P(CO(2)); (ii) varying tidal volume and respiratory rate so that alveolar ventilation is kept constant may change both PA(CO(2)) and the PA(CO(2))-PET(CO(2)) difference; (iii) the distributed model predicts higher end-tidal and arterial P(CO(2)) than the compartmental models under similar conditions; and (iv) P(CO(2)) capnograms predicted by the distributed model exhibit longer phase I and steeper phase II than other models. |
| spellingShingle | Whiteley, J Turner, M Baker, AB Gavaghan, D Hahn, C The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways. |
| title | The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways. |
| title_full | The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways. |
| title_fullStr | The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways. |
| title_full_unstemmed | The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways. |
| title_short | The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways. |
| title_sort | effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways |
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