NK cells and pre-eclampsia.
The immunological interaction between the mother and fetus has classically been thought of as one between paternal antigen and maternal T cells. However, the MHC antigen expression on human trophoblast and the immune cell populations present in the decidua suggest that this interaction primarily inv...
| Hauptverfasser: | , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2007
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| _version_ | 1826303950406549504 |
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| author | Sargent, I Borzychowski, A Redman, C |
| author_facet | Sargent, I Borzychowski, A Redman, C |
| author_sort | Sargent, I |
| collection | OXFORD |
| description | The immunological interaction between the mother and fetus has classically been thought of as one between paternal antigen and maternal T cells. However, the MHC antigen expression on human trophoblast and the immune cell populations present in the decidua suggest that this interaction primarily involves decidual NK cells rather than T cells, and this is supported by new functional studies. It is becoming apparent also that the maternal systemic immune response in pregnancy (Th1/Th2 shift) primarily involves NK cells. Aberrant NK cell activation both locally in the decidua and systemically in the maternal blood may be the cause of pre-eclampsia. |
| first_indexed | 2024-03-07T06:10:27Z |
| format | Journal article |
| id | oxford-uuid:ef4e5cdb-4532-4e22-8a00-2c5464d17a4a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:10:27Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:ef4e5cdb-4532-4e22-8a00-2c5464d17a4a2022-03-27T11:39:16ZNK cells and pre-eclampsia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef4e5cdb-4532-4e22-8a00-2c5464d17a4aEnglishSymplectic Elements at Oxford2007Sargent, IBorzychowski, ARedman, CThe immunological interaction between the mother and fetus has classically been thought of as one between paternal antigen and maternal T cells. However, the MHC antigen expression on human trophoblast and the immune cell populations present in the decidua suggest that this interaction primarily involves decidual NK cells rather than T cells, and this is supported by new functional studies. It is becoming apparent also that the maternal systemic immune response in pregnancy (Th1/Th2 shift) primarily involves NK cells. Aberrant NK cell activation both locally in the decidua and systemically in the maternal blood may be the cause of pre-eclampsia. |
| spellingShingle | Sargent, I Borzychowski, A Redman, C NK cells and pre-eclampsia. |
| title | NK cells and pre-eclampsia. |
| title_full | NK cells and pre-eclampsia. |
| title_fullStr | NK cells and pre-eclampsia. |
| title_full_unstemmed | NK cells and pre-eclampsia. |
| title_short | NK cells and pre-eclampsia. |
| title_sort | nk cells and pre eclampsia |
| work_keys_str_mv | AT sargenti nkcellsandpreeclampsia AT borzychowskia nkcellsandpreeclampsia AT redmanc nkcellsandpreeclampsia |