Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

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Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide p...

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Hlavní autoři: Bonilla, C, Lewis, S, Rowlands, M, Gaunt, T, Davey Smith, G, Gunnell, D, Palmer, T, Donovan, J, Hamdy, F, Neal, D, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, A, Benlloch, S, Muir, K, Giles, G, Wiklund, F, Grönberg, H, Haiman, C, Schleutker, J, Nordestgaard, B, Travis, R, Pashayan, N, Khaw, K, Stanford, J, Blot, W, Thibodeau, S, Maier, C, Kibel, A, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, M, Pandha, H, Lathrop, M, Martin, R, Holly, J
Médium: Journal article
Jazyk:English
Vydáno: Wiley 2016

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