PCSK6 is associated with handedness in individuals with dyslexia.
Approximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associ...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2011
|
| _version_ | 1826303975637385216 |
|---|---|
| author | Scerri, T Brandler, W Paracchini, S Morris, A Ring, S Richardson, A Talcott, J Stein, J Monaco, A |
| author_facet | Scerri, T Brandler, W Paracchini, S Morris, A Ring, S Richardson, A Talcott, J Stein, J Monaco, A |
| author_sort | Scerri, T |
| collection | OXFORD |
| description | Approximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associated marker, rs11855415 (P = 4.7 × 10(-7)), is located within PCSK6. Two independent cohorts with RD show the same trend, with the minor allele conferring greater relative right-hand skill. Meta-analysis of all three RD samples is genome-wide significant (n = 744, P = 2.0 × 10(-8)). Conversely, in the general population (n = 2666), we observe a trend towards reduced laterality of hand skill for the minor allele (P = 0.0020). These results provide molecular evidence that cerebral asymmetry and dyslexia are linked. Furthermore, PCSK6 is a protease that cleaves the left-right axis determining protein NODAL. Functional studies of PCSK6 promise insights into mechanisms underlying cerebral lateralization and dyslexia. |
| first_indexed | 2024-03-07T06:10:51Z |
| format | Journal article |
| id | oxford-uuid:ef70568e-02b3-45fb-bfb9-9b7e2d10e5b2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:10:51Z |
| publishDate | 2011 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:ef70568e-02b3-45fb-bfb9-9b7e2d10e5b22022-03-27T11:40:11ZPCSK6 is associated with handedness in individuals with dyslexia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef70568e-02b3-45fb-bfb9-9b7e2d10e5b2EnglishSymplectic Elements at OxfordOxford University Press2011Scerri, TBrandler, WParacchini, SMorris, ARing, SRichardson, ATalcott, JStein, JMonaco, AApproximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associated marker, rs11855415 (P = 4.7 × 10(-7)), is located within PCSK6. Two independent cohorts with RD show the same trend, with the minor allele conferring greater relative right-hand skill. Meta-analysis of all three RD samples is genome-wide significant (n = 744, P = 2.0 × 10(-8)). Conversely, in the general population (n = 2666), we observe a trend towards reduced laterality of hand skill for the minor allele (P = 0.0020). These results provide molecular evidence that cerebral asymmetry and dyslexia are linked. Furthermore, PCSK6 is a protease that cleaves the left-right axis determining protein NODAL. Functional studies of PCSK6 promise insights into mechanisms underlying cerebral lateralization and dyslexia. |
| spellingShingle | Scerri, T Brandler, W Paracchini, S Morris, A Ring, S Richardson, A Talcott, J Stein, J Monaco, A PCSK6 is associated with handedness in individuals with dyslexia. |
| title | PCSK6 is associated with handedness in individuals with dyslexia. |
| title_full | PCSK6 is associated with handedness in individuals with dyslexia. |
| title_fullStr | PCSK6 is associated with handedness in individuals with dyslexia. |
| title_full_unstemmed | PCSK6 is associated with handedness in individuals with dyslexia. |
| title_short | PCSK6 is associated with handedness in individuals with dyslexia. |
| title_sort | pcsk6 is associated with handedness in individuals with dyslexia |
| work_keys_str_mv | AT scerrit pcsk6isassociatedwithhandednessinindividualswithdyslexia AT brandlerw pcsk6isassociatedwithhandednessinindividualswithdyslexia AT paracchinis pcsk6isassociatedwithhandednessinindividualswithdyslexia AT morrisa pcsk6isassociatedwithhandednessinindividualswithdyslexia AT rings pcsk6isassociatedwithhandednessinindividualswithdyslexia AT richardsona pcsk6isassociatedwithhandednessinindividualswithdyslexia AT talcottj pcsk6isassociatedwithhandednessinindividualswithdyslexia AT steinj pcsk6isassociatedwithhandednessinindividualswithdyslexia AT monacoa pcsk6isassociatedwithhandednessinindividualswithdyslexia |