Genetic factors as determinants of infectious disease transmission in human communities.
Genetic factors may play an important role in individual susceptibility to infection. Hitherto this problem has been investigated by attempting to relate the distribution of genetic polymorphisms in populations to present or past infection, or by analysing specific infections by classical twin studi...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1988
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| _version_ | 1797102803423854592 |
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| author | Weatherall, D Bell, J Clegg, J Flint, J Higgs, D Hill, A Pasvol, G Thein, S |
| author_facet | Weatherall, D Bell, J Clegg, J Flint, J Higgs, D Hill, A Pasvol, G Thein, S |
| author_sort | Weatherall, D |
| collection | OXFORD |
| description | Genetic factors may play an important role in individual susceptibility to infection. Hitherto this problem has been investigated by attempting to relate the distribution of genetic polymorphisms in populations to present or past infection, or by analysing specific infections by classical twin studies or group comparisons. There is reasonable evidence that the common red-cell polymorphisms involving haemoglobin, enzymes or membrane have been maintained by relative resistance to malaria. Blood-group heterogeneity, including secretor status, may reflect varying susceptibility to bacterial, virus and yeast infection. There is increasing evidence that the HLA-DR system may be involved in modifying the clinical course of bacterial, virus and parasitic infection. So far no specific resistance or susceptibility loci similar to those found in murine models have been found in man. DNA analysis, particularly involving restriction fragment length polymorphism associations with candidate genes, offers a valuable new approach to this problem. |
| first_indexed | 2024-03-07T06:11:01Z |
| format | Journal article |
| id | oxford-uuid:ef7d31a1-5aa5-46a6-ae88-c3d526e6a8b9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:11:01Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:ef7d31a1-5aa5-46a6-ae88-c3d526e6a8b92022-03-27T11:40:38ZGenetic factors as determinants of infectious disease transmission in human communities.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef7d31a1-5aa5-46a6-ae88-c3d526e6a8b9EnglishSymplectic Elements at Oxford1988Weatherall, DBell, JClegg, JFlint, JHiggs, DHill, APasvol, GThein, SGenetic factors may play an important role in individual susceptibility to infection. Hitherto this problem has been investigated by attempting to relate the distribution of genetic polymorphisms in populations to present or past infection, or by analysing specific infections by classical twin studies or group comparisons. There is reasonable evidence that the common red-cell polymorphisms involving haemoglobin, enzymes or membrane have been maintained by relative resistance to malaria. Blood-group heterogeneity, including secretor status, may reflect varying susceptibility to bacterial, virus and yeast infection. There is increasing evidence that the HLA-DR system may be involved in modifying the clinical course of bacterial, virus and parasitic infection. So far no specific resistance or susceptibility loci similar to those found in murine models have been found in man. DNA analysis, particularly involving restriction fragment length polymorphism associations with candidate genes, offers a valuable new approach to this problem. |
| spellingShingle | Weatherall, D Bell, J Clegg, J Flint, J Higgs, D Hill, A Pasvol, G Thein, S Genetic factors as determinants of infectious disease transmission in human communities. |
| title | Genetic factors as determinants of infectious disease transmission in human communities. |
| title_full | Genetic factors as determinants of infectious disease transmission in human communities. |
| title_fullStr | Genetic factors as determinants of infectious disease transmission in human communities. |
| title_full_unstemmed | Genetic factors as determinants of infectious disease transmission in human communities. |
| title_short | Genetic factors as determinants of infectious disease transmission in human communities. |
| title_sort | genetic factors as determinants of infectious disease transmission in human communities |
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