Two pore channels (TPC2s) and nicotinic acid adenine dinucleotide phosphate (NAADP) at lysosomal-sarcoplasmic reticular junctions contribute to acute and chronic β-adrenoceptor signaling in the heart

Two pore channels (TPC2s) and nicotinic acid adenine dinucleotide phosphate (NAADP) at lysosomal-sarcoplasmic reticular junctions contribute to acute and chronic β-adrenoceptor signaling in the heart

Ca2+-permeable type 2 two-pore channels (TPC2) are lysosomal proteins required for nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca2+ release in many diverse cell types. Here, we investigate the importance of TPC2 proteins for the physiology and pathophysiology of the heart. NAADP-AM...

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Bibliographic Details
Main Authors:	Capel, R, Bolton, E, Lin, W, Aston, D, Wang, Y, Liu, W, Wang, X, Burton, R, Bloor-Young, D, Shade, K, Ruas, M, Parrington, J, Churchill, G, Lei, M, Galione, A, Terrar, D
Format:	Journal article
Published:	American Society for Biochemistry and Molecular Biology 2015

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