Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies
The effect of monoclonal anti-HLA antibodies on lysis of influenza virus-infected target cells by sensitized cytotoxic T lymphocytes was measured. Lysis was blocked, provided the antibody was present in a concentration sufficient to saturate the HLA determinants on the target cells. Antibodies to mo...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1980
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| _version_ | 1797102832657104896 |
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| author | Mcmichael, A Parham, P Brodsky, F Pilch, JR |
| author_facet | Mcmichael, A Parham, P Brodsky, F Pilch, JR |
| author_sort | Mcmichael, A |
| collection | OXFORD |
| description | The effect of monoclonal anti-HLA antibodies on lysis of influenza virus-infected target cells by sensitized cytotoxic T lymphocytes was measured. Lysis was blocked, provided the antibody was present in a concentration sufficient to saturate the HLA determinants on the target cells. Antibodies to monomorphic HLA determinants and to β2-microglobulin inhibited. Antibody to HLA A2 and B17 blocked lysis of target cells that shared these antigens with the effector cell. It was concluded that the restriction elements for influenza virus-specific cytotoxic T cells are the HLA molecules themselves. |
| first_indexed | 2024-03-07T06:11:23Z |
| format | Journal article |
| id | oxford-uuid:ef9fcbf2-6f4e-453a-bcd3-4c402003b062 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:11:23Z |
| publishDate | 1980 |
| record_format | dspace |
| spelling | oxford-uuid:ef9fcbf2-6f4e-453a-bcd3-4c402003b0622022-03-27T11:41:41ZInfluenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ef9fcbf2-6f4e-453a-bcd3-4c402003b062EnglishSymplectic Elements at Oxford1980Mcmichael, AParham, PBrodsky, FPilch, JRThe effect of monoclonal anti-HLA antibodies on lysis of influenza virus-infected target cells by sensitized cytotoxic T lymphocytes was measured. Lysis was blocked, provided the antibody was present in a concentration sufficient to saturate the HLA determinants on the target cells. Antibodies to monomorphic HLA determinants and to β2-microglobulin inhibited. Antibody to HLA A2 and B17 blocked lysis of target cells that shared these antigens with the effector cell. It was concluded that the restriction elements for influenza virus-specific cytotoxic T cells are the HLA molecules themselves. |
| spellingShingle | Mcmichael, A Parham, P Brodsky, F Pilch, JR Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies |
| title | Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies |
| title_full | Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies |
| title_fullStr | Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies |
| title_full_unstemmed | Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies |
| title_short | Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies |
| title_sort | influenza virus specific cytotoxic t lymphocytes recognize hla molecules blocking by monoclonal anti hla antibodies |
| work_keys_str_mv | AT mcmichaela influenzavirusspecificcytotoxictlymphocytesrecognizehlamoleculesblockingbymonoclonalantihlaantibodies AT parhamp influenzavirusspecificcytotoxictlymphocytesrecognizehlamoleculesblockingbymonoclonalantihlaantibodies AT brodskyf influenzavirusspecificcytotoxictlymphocytesrecognizehlamoleculesblockingbymonoclonalantihlaantibodies AT pilchjr influenzavirusspecificcytotoxictlymphocytesrecognizehlamoleculesblockingbymonoclonalantihlaantibodies |