Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required for centriole assembly, but it is unclear how...

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Bibliographic Details
Main Authors:	Cottee, M, Muschalik, N, Wong, Y, Johnson, C, Johnson, S, Andreeva, A, Oegema, K, Lea, S, Raff, J, Van Breugel, M
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications 2013

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