Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development?
OBJECTIVE We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally...
| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Conference item |
| Sprache: | English |
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American Diabetes Association
2017
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| _version_ | 1826304028944891904 |
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| author | Ferrara, CT Geyer, SM Liu, Y-F Evans-Molina, C Libman, IM Besser, R Becker, DJ Rodriguez, H Moran, A Gitelman, SE Redondo, MJ Type 1 Diabetes TrialNet Study Group |
| author_facet | Ferrara, CT Geyer, SM Liu, Y-F Evans-Molina, C Libman, IM Besser, R Becker, DJ Rodriguez, H Moran, A Gitelman, SE Redondo, MJ Type 1 Diabetes TrialNet Study Group |
| author_sort | Ferrara, CT |
| collection | OXFORD |
| description | OBJECTIVE We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.
RESEARCH DESIGN AND METHODS We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk.
RESULTS Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males.
CONCLUSIONS Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.
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| first_indexed | 2024-03-07T06:11:38Z |
| format | Conference item |
| id | oxford-uuid:efb41e22-5c2c-42f2-b307-f51b531041e7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:11:38Z |
| publishDate | 2017 |
| publisher | American Diabetes Association |
| record_format | dspace |
| spelling | oxford-uuid:efb41e22-5c2c-42f2-b307-f51b531041e72022-03-27T11:42:13ZExcess BMI in childhood: a modifiable risk factor for type 1 diabetes development?Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:efb41e22-5c2c-42f2-b307-f51b531041e7EnglishSymplectic ElementsAmerican Diabetes Association2017Ferrara, CTGeyer, SMLiu, Y-FEvans-Molina, CLibman, IMBesser, RBecker, DJRodriguez, HMoran, AGitelman, SERedondo, MJType 1 Diabetes TrialNet Study GroupOBJECTIVE We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age. |
| spellingShingle | Ferrara, CT Geyer, SM Liu, Y-F Evans-Molina, C Libman, IM Besser, R Becker, DJ Rodriguez, H Moran, A Gitelman, SE Redondo, MJ Type 1 Diabetes TrialNet Study Group Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development? |
| title | Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development? |
| title_full | Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development? |
| title_fullStr | Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development? |
| title_full_unstemmed | Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development? |
| title_short | Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development? |
| title_sort | excess bmi in childhood a modifiable risk factor for type 1 diabetes development |
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