Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19

Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID-19. Complement activation products are detected in plasma and tissues and complement blockade considered for therapy. To delineate roles of complement in immunopathogenesis, we undertook the large...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Siggins, M, Davies, K, Fellows, R, Thwaites, R, Baillie, K, Semple, M, Openshaw, P, Zelek, W, Harris, CL, Morgan, BP, Dunning, W
Awduron Eraill:	The ISARIC4C Investigators
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Wiley 2022

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