Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19

Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID-19. Complement activation products are detected in plasma and tissues and complement blockade considered for therapy. To delineate roles of complement in immunopathogenesis, we undertook the large...

Podrobná bibliografie
Hlavní autoři:	Siggins, M, Davies, K, Fellows, R, Thwaites, R, Baillie, K, Semple, M, Openshaw, P, Zelek, W, Harris, CL, Morgan, BP, Dunning, W
Další autoři:	The ISARIC4C Investigators
Médium:	Journal article
Jazyk:	English
Vydáno:	Wiley 2022

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