Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19

Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID-19. Complement activation products are detected in plasma and tissues and complement blockade considered for therapy. To delineate roles of complement in immunopathogenesis, we undertook the large...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Siggins, M, Davies, K, Fellows, R, Thwaites, R, Baillie, K, Semple, M, Openshaw, P, Zelek, W, Harris, CL, Morgan, BP, Dunning, W
Бусад зохиолчид:	The ISARIC4C Investigators
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Wiley 2022

Ижил төстэй зүйлс

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species
-н: Wioleta M. Zelek, зэрэг
Хэвлэсэн: (2020-12-01)

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
-н: Sarah M. Carpanini, зэрэг
Хэвлэсэн: (2022-07-01)

Dysregulation of complement system in HELLP syndrome
-н: Shi Chen, зэрэг
Хэвлэсэн: (2021-10-01)

Measuring Total Classical Pathway and Activities of Individual Components of the Mouse Complement Pathway
-н: Wioleta Zelek
Хэвлэсэн: (2021-10-01)

Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study
-н: Amer Toutonji, зэрэг
Хэвлэсэн: (2021-07-01)

Seasonal and pandemic influenza: 100 years of progress, still much to learn
-н: Dunning, WJ, зэрэг
Хэвлэсэн: (2020)

Delayed mucosal antiviral responses despite robust peripheral inflammation in fatal COVID-19
-н: Sidhu, JK, зэрэг
Хэвлэсэн: (2023)

Complement dysregulation is associated with severe COVID-19 illness
-н: Jia Yu, зэрэг
Хэвлэсэн: (2021-07-01)

Commentary on “Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes”
-н: Patty P.A. Dhooge, зэрэг
Хэвлэсэн: (2021-09-01)

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
-н: Kristin Hartmann, зэрэг
Хэвлэсэн: (2019-05-01)

Dysregulation of complement system in neuropsychiatric disorders: A mini review
-н: Danny Perez Sierra, зэрэг
Хэвлэсэн: (2022-12-01)

Dysregulation of Complement Activation and Placental Dysfunction: A Potential Target to Treat Preeclampsia?
-н: E. Pierik, зэрэг
Хэвлэсэн: (2020-01-01)

Kinetic analysis of the interaction between the complement regulators CD46 and CD55 and components of the alternative pathway of complement
-н: Harris, C, зэрэг
Хэвлэсэн: (2004)

Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
-н: Aurora Veteleanu, зэрэг
Хэвлэсэн: (2023-07-01)

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
-н: Alexandra E. Butler, зэрэг
Хэвлэсэн: (2023-08-01)

Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes
-н: Jane Hu, зэрэг
Хэвлэсэн: (2020-10-01)

Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.
-н: Alexessander Couto Alves, зэрэг
Хэвлэсэн: (2013-01-01)

CFTR dysregulation drives active selection of the gut microbiome.
-н: Stacey M Meeker, зэрэг
Хэвлэсэн: (2020-01-01)

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
-н: Thwaites, RS, зэрэг
Хэвлэсэн: (2021)

Longitudinal Stroke Recovery Associated With Dysregulation of Complement System—A Proteomics Pathway Analysis
-н: Vinh A. Nguyen, зэрэг
Хэвлэсэн: (2020-07-01)

Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come
-н: Saskia F. Heeringa, зэрэг
Хэвлэсэн: (2012-01-01)

Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants
-н: Mohammad Afzal Khan, зэрэг
Хэвлэсэн: (2020-03-01)

P791: COMMON VARIANTS IN COMPLEMENT PROTEINS, C3 AND CR1, ENHANCE COMPLEMENT ATTACK ON PNH ERYTHROCYTES AND INCREASE RISK FOR EXTRAVASCULAR HAEMOLYSIS
-н: A. J. Baral, зэрэг
Хэвлэсэн: (2022-06-01)

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation
-н: Jin Y. Chen, зэрэг
Хэвлэсэн: (2020-07-01)

Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport
-н: Aleksha Panwar, зэрэг
Хэвлэсэн: (2023-06-01)

The role of complement in the clinical course of hepatocellular carcinoma
-н: Xinye Qian, зэрэг
Хэвлэсэн: (2022-03-01)

Type 2 Diabetes Mellitus Aggravates Complement Dysregulation and Affects Cortisol Response in Patients with Post-COVID-19
-н: Ji W, зэрэг
Хэвлэсэн: (2024-10-01)

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.
-н: Nicola N Lynskey, зэрэг
Хэвлэсэн: (2017-08-01)

Menstruation Dysregulation and Endometriosis Development
-н: Kevin K. W. Kuan, зэрэг
Хэвлэсэн: (2021-10-01)

Structures of the rat complement regulator CrrY
-н: Roversi, P, зэрэг
Хэвлэсэн: (2011)

Structures of the rat complement regulator CrrY.
-н: Roversi, P, зэрэг
Хэвлэсэн: (2011)

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation
-н: Pooja Shivshankar, зэрэг
Хэвлэсэн: (2025-02-01)

Complement Activation in the Central Nervous System: A Biophysical Model for Immune Dysregulation in the Disease State
-н: Nicholas Peoples, зэрэг
Хэвлэсэн: (2021-03-01)

Identification of Dysregulated Complement Activation Pathways Driven by N-Glycosylation Alterations in T2D Patients
-н: Yang Zhao, зэрэг
Хэвлэсэн: (2021-06-01)

Acquired partial lipodystrophy and C3 glomerulopathy: Dysregulation of the complement system as a common mechanism
-н: Fernando Corvillo, зэрэг
Хэвлэсэн: (2018-05-01)

Complement biomarkers as predictors of disease progression in Alzheimer's disease.
-н: Hakobyan, S, зэрэг
Хэвлэсэн: (2016)

Obesity dysregulates the pulmonary antiviral immune response
-н: Almond, M, зэрэг
Хэвлэсэн: (2023)

Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID‐19: Analysis of the ISARIC CCP‐UK cohort
-н: Yates, T, зэрэг
Хэвлэсэн: (2021)

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis
-н: Eva M Buhl, зэрэг
Хэвлэсэн: (2020-01-01)

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus
-н: Calvin V. Lieu, зэрэг
Хэвлэсэн: (2021-11-01)