Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America.
Clusters of meningococcal disease caused by a hyperinvasive lineage of Neisseria meningitidis, the ST11 complex, bearing a serogroup C polysaccharide capsule, have been prominent in Europe and North America since the early 1990s. This situation has led to expensive public health measures for outbrea...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1826304043848302592 |
|---|---|
| author | Pollard, A Ochnio, J Ho, M Callaghan, M Bigham, M Dobsong, S |
| author_facet | Pollard, A Ochnio, J Ho, M Callaghan, M Bigham, M Dobsong, S |
| author_sort | Pollard, A |
| collection | OXFORD |
| description | Clusters of meningococcal disease caused by a hyperinvasive lineage of Neisseria meningitidis, the ST11 complex, bearing a serogroup C polysaccharide capsule, have been prominent in Europe and North America since the early 1990s. This situation has led to expensive public health measures for outbreak control and, finally, to the introduction of a serogroup C glyconjugate vaccine into the primary immunization schedule in the United Kingdom and elsewhere. ST11 complex meningococci may also express serogroup W135 polysaccharide capsules. We investigated the level of population immunity to this hyperinvasive clone in association with the appearance of outbreaks of meningococcal disease in southern British Columbia. We found that most adults and almost all children were apparently susceptible to infection with ST11 complex meningococci bearing both C and W135 polysaccharide capsules, which suggests that a vaccine program directed against only serogroup C meningococci may be insufficient to prevent hyperinvasive ST11 disease. |
| first_indexed | 2024-03-07T06:11:51Z |
| format | Journal article |
| id | oxford-uuid:efc7f33a-b204-46e5-aa32-c098d917be62 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:11:51Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:efc7f33a-b204-46e5-aa32-c098d917be622022-03-27T11:42:46ZDisease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:efc7f33a-b204-46e5-aa32-c098d917be62EnglishSymplectic Elements at Oxford2004Pollard, AOchnio, JHo, MCallaghan, MBigham, MDobsong, SClusters of meningococcal disease caused by a hyperinvasive lineage of Neisseria meningitidis, the ST11 complex, bearing a serogroup C polysaccharide capsule, have been prominent in Europe and North America since the early 1990s. This situation has led to expensive public health measures for outbreak control and, finally, to the introduction of a serogroup C glyconjugate vaccine into the primary immunization schedule in the United Kingdom and elsewhere. ST11 complex meningococci may also express serogroup W135 polysaccharide capsules. We investigated the level of population immunity to this hyperinvasive clone in association with the appearance of outbreaks of meningococcal disease in southern British Columbia. We found that most adults and almost all children were apparently susceptible to infection with ST11 complex meningococci bearing both C and W135 polysaccharide capsules, which suggests that a vaccine program directed against only serogroup C meningococci may be insufficient to prevent hyperinvasive ST11 disease. |
| spellingShingle | Pollard, A Ochnio, J Ho, M Callaghan, M Bigham, M Dobsong, S Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. |
| title | Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. |
| title_full | Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. |
| title_fullStr | Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. |
| title_full_unstemmed | Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. |
| title_short | Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. |
| title_sort | disease susceptibility to st11 complex meningococci bearing serogroup c or w135 polysaccharide capsules north america |
| work_keys_str_mv | AT pollarda diseasesusceptibilitytost11complexmeningococcibearingserogroupcorw135polysaccharidecapsulesnorthamerica AT ochnioj diseasesusceptibilitytost11complexmeningococcibearingserogroupcorw135polysaccharidecapsulesnorthamerica AT hom diseasesusceptibilitytost11complexmeningococcibearingserogroupcorw135polysaccharidecapsulesnorthamerica AT callaghanm diseasesusceptibilitytost11complexmeningococcibearingserogroupcorw135polysaccharidecapsulesnorthamerica AT bighamm diseasesusceptibilitytost11complexmeningococcibearingserogroupcorw135polysaccharidecapsulesnorthamerica AT dobsongs diseasesusceptibilitytost11complexmeningococcibearingserogroupcorw135polysaccharidecapsulesnorthamerica |