Thera-SAbDab: the Therapeutic Structural Antibody Database
The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDa...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2019
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| _version_ | 1797102881248116736 |
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| author | Raybould, MIJ Marks, C Lewis, Alan P Shi, J Shi, J Bujotzek, A Taddese, B Deane, C |
| author_facet | Raybould, MIJ Marks, C Lewis, Alan P Shi, J Shi, J Bujotzek, A Taddese, B Deane, C |
| author_sort | Raybould, MIJ |
| collection | OXFORD |
| description | The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5 August 2019) are downloadable as a single file with accompanying metadata. |
| first_indexed | 2024-03-07T06:12:06Z |
| format | Journal article |
| id | oxford-uuid:efe084ca-8409-4af4-ae36-47dcb9c9d75d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:12:06Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:efe084ca-8409-4af4-ae36-47dcb9c9d75d2022-03-27T11:43:27ZThera-SAbDab: the Therapeutic Structural Antibody DatabaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:efe084ca-8409-4af4-ae36-47dcb9c9d75dEnglishSymplectic Elements at OxfordOxford University Press2019Raybould, MIJMarks, CLewis, Alan P Shi, J Shi, JBujotzek, ATaddese, BDeane, CThe Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5 August 2019) are downloadable as a single file with accompanying metadata. |
| spellingShingle | Raybould, MIJ Marks, C Lewis, Alan P Shi, J Shi, J Bujotzek, A Taddese, B Deane, C Thera-SAbDab: the Therapeutic Structural Antibody Database |
| title | Thera-SAbDab: the Therapeutic Structural Antibody Database |
| title_full | Thera-SAbDab: the Therapeutic Structural Antibody Database |
| title_fullStr | Thera-SAbDab: the Therapeutic Structural Antibody Database |
| title_full_unstemmed | Thera-SAbDab: the Therapeutic Structural Antibody Database |
| title_short | Thera-SAbDab: the Therapeutic Structural Antibody Database |
| title_sort | thera sabdab the therapeutic structural antibody database |
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