Towards the development of multi-disease vaccines against arthropod-borne viruses
<p>Once considered neglected tropical diseases, arthropod-borne viruses are one of the biggest threats to global health today. Resulting in hundreds of millions of infections each year, the burden associated to the epidemics of mosquito-borne viruses results in significant human and economic l...
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| Formato: | Thesis |
| Idioma: | English |
| Publicado: |
2022
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| _version_ | 1826312917613543424 |
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| author | Montalvo Zurbía Flores, G |
| author2 | Reyes Sandoval, A |
| author_facet | Reyes Sandoval, A Montalvo Zurbía Flores, G |
| author_sort | Montalvo Zurbía Flores, G |
| collection | OXFORD |
| description | <p>Once considered neglected tropical diseases, arthropod-borne viruses are one of the biggest threats to global health today. Resulting in hundreds of millions of infections each year, the burden associated to the epidemics of mosquito-borne viruses results in significant human and economic losses. The need to implement intervention methods against these pathogens has been further highlighted by the recent widespread of their epidemics and the increasing expansion of their vector populations in non-endemic areas. Nevertheless, the number of licensed vaccines for widespread human use is limited to two: one against yellow fever virus and another against Japanese encephalitis virus.</p>
<p>Even when novel vaccines are available, individual vaccine regimens might not be efficient enough to contain their epidemics; specially if we consider that many of these viruses co-exist in the same geographical regions, can be transmitted by the same vector species, and often cause co-infections. Focusing particularly on dengue, chikungunya, zika, and yellow fever, this thesis aims to develop strategies for the generation of a novel multi-disease vaccines by either, (i) investigating the immunological outcome of the co-administration of multiple viral vectored vaccines in preclinical models, whilst considering features of different vaccine regimes and vaccine dosing (ii) exploring strategies for the development of multi-pathogen vaccines co-expressing several antigens from different pathogens, and (iii) designing novel viral vectored vaccines as an alternative to the already existing yellow fever vaccines.</p> |
| first_indexed | 2024-09-25T04:02:46Z |
| format | Thesis |
| id | oxford-uuid:efe829c5-277d-4d8f-b092-8051ba7037ae |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:02:46Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | oxford-uuid:efe829c5-277d-4d8f-b092-8051ba7037ae2024-05-02T09:16:23ZTowards the development of multi-disease vaccines against arthropod-borne virusesThesishttp://purl.org/coar/resource_type/c_db06uuid:efe829c5-277d-4d8f-b092-8051ba7037aeVaccinologyImmunologyClinical medicineEnglishHyrax Deposit2022Montalvo Zurbía Flores, GReyes Sandoval, ARollier Weissenburger, CPreciado Llanes, LGilbert, RDold, CMilicic, A<p>Once considered neglected tropical diseases, arthropod-borne viruses are one of the biggest threats to global health today. Resulting in hundreds of millions of infections each year, the burden associated to the epidemics of mosquito-borne viruses results in significant human and economic losses. The need to implement intervention methods against these pathogens has been further highlighted by the recent widespread of their epidemics and the increasing expansion of their vector populations in non-endemic areas. Nevertheless, the number of licensed vaccines for widespread human use is limited to two: one against yellow fever virus and another against Japanese encephalitis virus.</p> <p>Even when novel vaccines are available, individual vaccine regimens might not be efficient enough to contain their epidemics; specially if we consider that many of these viruses co-exist in the same geographical regions, can be transmitted by the same vector species, and often cause co-infections. Focusing particularly on dengue, chikungunya, zika, and yellow fever, this thesis aims to develop strategies for the generation of a novel multi-disease vaccines by either, (i) investigating the immunological outcome of the co-administration of multiple viral vectored vaccines in preclinical models, whilst considering features of different vaccine regimes and vaccine dosing (ii) exploring strategies for the development of multi-pathogen vaccines co-expressing several antigens from different pathogens, and (iii) designing novel viral vectored vaccines as an alternative to the already existing yellow fever vaccines.</p> |
| spellingShingle | Vaccinology Immunology Clinical medicine Montalvo Zurbía Flores, G Towards the development of multi-disease vaccines against arthropod-borne viruses |
| title | Towards the development of multi-disease vaccines against arthropod-borne viruses |
| title_full | Towards the development of multi-disease vaccines against arthropod-borne viruses |
| title_fullStr | Towards the development of multi-disease vaccines against arthropod-borne viruses |
| title_full_unstemmed | Towards the development of multi-disease vaccines against arthropod-borne viruses |
| title_short | Towards the development of multi-disease vaccines against arthropod-borne viruses |
| title_sort | towards the development of multi disease vaccines against arthropod borne viruses |
| topic | Vaccinology Immunology Clinical medicine |
| work_keys_str_mv | AT montalvozurbiafloresg towardsthedevelopmentofmultidiseasevaccinesagainstarthropodborneviruses |