Flexible metathesis-based approaches to highly functionalised furans and pyrroles

Flexible metathesis-based approaches to highly functionalised furans and pyrroles

A range of differentially functionalised furans and pyrroles have been synthesised in short order by the judicious use of a ring-closing metathesis/aromatisation strategy. Two contrasting approaches are described exploiting a palladium-catalysed union of allylic alcohols and sulfonamides in one case...

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Hlavní autoři: Donohoe, T, Kershaw, N, Orr, A, Wheelhouse nee Gosby, K, Fishlock, L, Lacy, A, Bingham, M, Procopiou, P
Médium: Journal article
Jazyk:English
Vydáno: 2008
Popis
Shrnutí:A range of differentially functionalised furans and pyrroles have been synthesised in short order by the judicious use of a ring-closing metathesis/aromatisation strategy. Two contrasting approaches are described exploiting a palladium-catalysed union of allylic alcohols and sulfonamides in one case, and a titanium mediated methylenation of homoallylic esters in another. A number of groups that are difficult to install via traditional methods were incorporated successfully. © 2007 Elsevier Ltd. All rights reserved.

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