TDP-43 based biomarker development in amyotrophic lateral sclerosis

TDP-43 based biomarker development in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease which is clinically and aetiologically heterogenous. However, TDP-43 neuropathology is a unifying hallmark found in 97% of ALS cases. Understanding the common pathological pathways downstream of TDP-43 dysregulation is essentia...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Feneberg, E
Awduron Eraill:	Turner, M
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2019
Pynciau:	Proteomics Nervous system > Degeneration Molecular neurobiology Amyotrophic lateral sclerosis

Eitemau Tebyg

Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis
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Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions
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Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
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TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
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TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis
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Editorial: New Insights Into the Molecular Mechanism of Amyotrophic Lateral Sclerosis Pathogenesis
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The effect of pH alterations on TDP-43 in a cellular model of amyotrophic lateral sclerosis
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TDP-43 Proteinopathy Specific Biomarker Development
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Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis
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A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
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Current insights in the molecular genetic pathogenesis of amyotrophic lateral sclerosis
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Analysis of Heart Rate Variability in Individuals Affected by Amyotrophic Lateral Sclerosis
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Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis
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Cyhoeddwyd: (2025-02-01)

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Proteomics Analysis of Lymphoblastoid Cell Lines from Patients with Amyotrophic Lateral Sclerosis
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A Computational Approach to Investigate TDP-43 RNA-Recognition Motif 2 C-Terminal Fragments Aggregation in Amyotrophic Lateral Sclerosis
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Cyhoeddwyd: (2021-12-01)

Altered TDP-43 Structure and Function: Key Insights into Aberrant RNA, Mitochondrial, and Cellular and Systemic Metabolism in Amyotrophic Lateral Sclerosis
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TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
gan: Rachel Atkinson, et al.
Cyhoeddwyd: (2021-02-01)

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain
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Amyotrophic Lateral Sclerosis: A Diet Review
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Pain in Amyotrophic Lateral Sclerosis Is Underrated
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Cyhoeddwyd: (2024-12-01)

Evaluation of Dysphagia in Amyotrophic Lateral Sclerosis
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Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis
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Cyhoeddwyd: (2025-02-01)

Cerebrospinal Fluid Chitinases as Biomarkers for Amyotrophic Lateral Sclerosis
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New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022
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Progress in clinical diagnosis of amyotrophic lateral sclerosis
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Cyhoeddwyd: (2012-06-01)