Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the aut...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797102913858830336 |
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| author | Parkes, M Barrett, J Prescott, N Tremelling, M Anderson, C Fisher, SA Roberts, R Nimmo, E Cummings, F Soars, D Drummond, H Lees, C Khawaja, SA Bagnall, R Burke, D Todhunter, C Ahmad, T Onnie, C McArdle, W Strachan, D Bethel, G Bryan, C Lewis, C Deloukas, P Forbes, A |
| author_facet | Parkes, M Barrett, J Prescott, N Tremelling, M Anderson, C Fisher, SA Roberts, R Nimmo, E Cummings, F Soars, D Drummond, H Lees, C Khawaja, SA Bagnall, R Burke, D Todhunter, C Ahmad, T Onnie, C McArdle, W Strachan, D Bethel, G Bryan, C Lewis, C Deloukas, P Forbes, A |
| author_sort | Parkes, M |
| collection | OXFORD |
| description | A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13. |
| first_indexed | 2024-03-07T06:12:35Z |
| format | Journal article |
| id | oxford-uuid:f009b13b-5471-43b5-8858-be5ec4b8d2d1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:12:35Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:f009b13b-5471-43b5-8858-be5ec4b8d2d12022-03-27T11:44:42ZSequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f009b13b-5471-43b5-8858-be5ec4b8d2d1EnglishSymplectic Elements at Oxford2007Parkes, MBarrett, JPrescott, NTremelling, MAnderson, CFisher, SARoberts, RNimmo, ECummings, FSoars, DDrummond, HLees, CKhawaja, SABagnall, RBurke, DTodhunter, CAhmad, TOnnie, CMcArdle, WStrachan, DBethel, GBryan, CLewis, CDeloukas, PForbes, AA genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13. |
| spellingShingle | Parkes, M Barrett, J Prescott, N Tremelling, M Anderson, C Fisher, SA Roberts, R Nimmo, E Cummings, F Soars, D Drummond, H Lees, C Khawaja, SA Bagnall, R Burke, D Todhunter, C Ahmad, T Onnie, C McArdle, W Strachan, D Bethel, G Bryan, C Lewis, C Deloukas, P Forbes, A Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. |
| title | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. |
| title_full | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. |
| title_fullStr | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. |
| title_full_unstemmed | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. |
| title_short | Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. |
| title_sort | sequence variants in the autophagy gene irgm and multiple other replicating loci contribute to crohn s disease susceptibility |
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