Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the aut...

Podrobná bibliografie
Hlavní autoři:	Parkes, M, Barrett, J, Prescott, N, Tremelling, M, Anderson, C, Fisher, SA, Roberts, R, Nimmo, E, Cummings, F, Soars, D, Drummond, H, Lees, C, Khawaja, SA, Bagnall, R, Burke, D, Todhunter, C, Ahmad, T, Onnie, C, McArdle, W, Strachan, D, Bethel, G, Bryan, C, Lewis, C, Deloukas, P, Forbes, A
Médium:	Journal article
Jazyk:	English
Vydáno:	2007

Podobné jednotky

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
Autor: Anderson, C, a další
Vydáno: (2009)

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Autor: Fisher, SA, a další
Vydáno: (2008)

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Autor: Fisher, SA, a další
Vydáno: (2008)

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
Autor: Tremelling, M, a další
Vydáno: (2007)

Death and resurrection of the human IRGM gene.
Autor: Cemalettin Bekpen, a další
Vydáno: (2009-03-01)

Role of Mutations in NOD2/CARD15, ATG16L1, and IRGM in the Pathogenesis of Crohn’s Disease
Autor: Igor’ V. Maev, a další
Vydáno: (2014-03-01)

Association between variants of the autophagy related gene--IRGM and susceptibility to Crohn's disease and ulcerative colitis: a meta-analysis.
Autor: Xiao Cheng Lu, a další
Vydáno: (2013-01-01)

IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure
Autor: Xing Zhang, a další
Vydáno: (2024-06-01)

The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?
Autor: Julia P Hunn, a další
Vydáno: (2010-01-01)

Genotyping of IRGM tetranucleotide promoter oligorepeats by fluorescence resonance energy transfer
Autor: Christopher D. Intemann, a další
Vydáno: (2009-01-01)

Irgm1 regulates metabolism and function in T cell subsets
Autor: Yazan Alwarawrah, a další
Vydáno: (2022-01-01)

The impact of NOD2 variants on fecal microbiota in Crohn's Disease and controls without gastrointestinal disease
Autor: Kennedy, N, a další
Vydáno: (2018)

IRGM variants and susceptibility to inflammatory bowel disease in the German population.
Autor: Jürgen Glas, a další
Vydáno: (2013-01-01)

mSphere of Influence: Role of IRGM1 in Disease Control
Autor: Sumanta Kumar Naik
Vydáno: (2021-04-01)

Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.
Autor: Stanley C Henry, a další
Vydáno: (2014-01-01)

In situ hybridisation for human defensins, lysozyme, spla2 and TNF alpha in Crohn's disease and controls
Autor: Todhunter, C, a další
Vydáno: (2007)

Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection
Autor: Jacob Dockterman, a další
Vydáno: (2024-04-01)

Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.
Autor: Yang O Zhao, a další
Vydáno: (2010-01-01)

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.
Autor: van Heel, D, a další
Vydáno: (2005)

Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran
Autor: Gholamreza Bahari, a další
Vydáno: (2012-01-01)

IRGM is a common target of RNA viruses that subvert the autophagy network.
Autor: Isabel Pombo Grégoire, a další
Vydáno: (2011-12-01)

Race-specific association of an IRGM risk allele with cytokine expression in human subjects
Autor: Teminioluwa Ajayi, a další
Vydáno: (2023-08-01)

Sarcoidosis complicating treatment with natalizumab for Crohn's disease
Autor: Parisinos, C, a další
Vydáno: (2011)

IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.
Autor: Arun K Haldar, a další
Vydáno: (2013-01-01)

The Stokes boundary layer for a thixotropic or antithixotropic fluid
Autor: McArdle, C, a další
Vydáno: (2012)

IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice
Autor: Prashant Rai, a další
Vydáno: (2023-11-01)

Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
Autor: Christopher D Intemann, a další
Vydáno: (2009-09-01)

Side chain liquid crystal polymers /
Autor: McArdle, C. B.
Vydáno: (1989)

IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application
Autor: Linlu Tian, a další
Vydáno: (2021-03-01)

Review article: the management of severe Crohn's disease.
Autor: Parkes, M, a další
Vydáno: (2001)

Fistulating anal Crohn's disease: results of combined surgical and infliximab treatment.
Autor: Hyder, SA, a další
Vydáno: (2006)

Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn’s disease
Autor: Polley, S, a další
Vydáno: (2016)

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn’s disease
Autor: Noble, C, a další
Vydáno: (2005)

Fulminant Crohn's colitis after allogeneic stem cell transplantation.
Autor: Sonwalkar, SA, a další
Vydáno: (2003)

Crohn's disease and pregnancy.
Autor: Khosla, R, a další
Vydáno: (1984)

Association of IRGM (rs1000113 C/T) Genetic Polymorphism with the Incidence of Acute Rejection in Iranian Liver Transplanted Patients
Autor: Zahra Malekpour, a další
Vydáno: (2019-11-01)

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.
Autor: Gregory A Taylor, a další
Vydáno: (2020-05-01)

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice
Autor: Allison R. Rogala, a další
Vydáno: (2018-02-01)

Molecular genetics of Crohn's disease: recent advances.
Autor: Satsangi, J, a další
Vydáno: (1998)

TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM
Autor: Mingchuang Sun, a další
Vydáno: (2023-10-01)