Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the aut...
Հիմնական հեղինակներ: | Parkes, M, Barrett, J, Prescott, N, Tremelling, M, Anderson, C, Fisher, SA, Roberts, R, Nimmo, E, Cummings, F, Soars, D, Drummond, H, Lees, C, Khawaja, SA, Bagnall, R, Burke, D, Todhunter, C, Ahmad, T, Onnie, C, McArdle, W, Strachan, D, Bethel, G, Bryan, C, Lewis, C, Deloukas, P, Forbes, A |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2007
|
Նմանատիպ նյութեր
-
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
: Anderson, C, և այլն
Հրապարակվել է: (2009) -
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
: Fisher, SA, և այլն
Հրապարակվել է: (2008) -
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
: Fisher, SA, և այլն
Հրապարակվել է: (2008) -
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
: Tremelling, M, և այլն
Հրապարակվել է: (2007) -
Death and resurrection of the human IRGM gene.
: Cemalettin Bekpen, և այլն
Հրապարակվել է: (2009-03-01)