Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude.
This review of ventilatory acclimatization to altitude/hypoxia (VAH) emphasizes the widely differing timescales that VAH is considered to encompass. The review concludes: (1) that early (24-48h) VAH is unlikely to arise as a reaction to the respiratory alkalosis that is normally associated with expo...
| Tác giả chính: | |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2007
|
| Tóm tắt: | This review of ventilatory acclimatization to altitude/hypoxia (VAH) emphasizes the widely differing timescales that VAH is considered to encompass. The review concludes: (1) that early (24-48h) VAH is unlikely to arise as a reaction to the respiratory alkalosis that is normally associated with exposure to hypoxia; (2) that changes in peripheral chemoreflex function may be sufficiently rapid to explain early VAH; (3) that alterations in gene expression induced by hypoxia through the hypoxia-inducible factor (HIF) signalling pathway may underlie a major component of VAH; and (4) that compensatory adjustments to acid-base balance in response to the initial respiratory alkalosis may have more significance for the slower changes observed later in VAH. |
|---|