Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude.
This review of ventilatory acclimatization to altitude/hypoxia (VAH) emphasizes the widely differing timescales that VAH is considered to encompass. The review concludes: (1) that early (24-48h) VAH is unlikely to arise as a reaction to the respiratory alkalosis that is normally associated with expo...
| Autor Principal: | |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2007
|
| _version_ | 1826304096167002112 |
|---|---|
| author | Robbins, P |
| author_facet | Robbins, P |
| author_sort | Robbins, P |
| collection | OXFORD |
| description | This review of ventilatory acclimatization to altitude/hypoxia (VAH) emphasizes the widely differing timescales that VAH is considered to encompass. The review concludes: (1) that early (24-48h) VAH is unlikely to arise as a reaction to the respiratory alkalosis that is normally associated with exposure to hypoxia; (2) that changes in peripheral chemoreflex function may be sufficiently rapid to explain early VAH; (3) that alterations in gene expression induced by hypoxia through the hypoxia-inducible factor (HIF) signalling pathway may underlie a major component of VAH; and (4) that compensatory adjustments to acid-base balance in response to the initial respiratory alkalosis may have more significance for the slower changes observed later in VAH. |
| first_indexed | 2024-03-07T06:12:36Z |
| format | Journal article |
| id | oxford-uuid:f00b65be-1c4c-42f2-a17f-9b5631541490 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:12:36Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:f00b65be-1c4c-42f2-a17f-9b56315414902022-03-27T11:44:42ZRole of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f00b65be-1c4c-42f2-a17f-9b5631541490EnglishSymplectic Elements at Oxford2007Robbins, PThis review of ventilatory acclimatization to altitude/hypoxia (VAH) emphasizes the widely differing timescales that VAH is considered to encompass. The review concludes: (1) that early (24-48h) VAH is unlikely to arise as a reaction to the respiratory alkalosis that is normally associated with exposure to hypoxia; (2) that changes in peripheral chemoreflex function may be sufficiently rapid to explain early VAH; (3) that alterations in gene expression induced by hypoxia through the hypoxia-inducible factor (HIF) signalling pathway may underlie a major component of VAH; and (4) that compensatory adjustments to acid-base balance in response to the initial respiratory alkalosis may have more significance for the slower changes observed later in VAH. |
| spellingShingle | Robbins, P Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. |
| title | Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. |
| title_full | Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. |
| title_fullStr | Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. |
| title_full_unstemmed | Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. |
| title_short | Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. |
| title_sort | role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude |
| work_keys_str_mv | AT robbinsp roleoftheperipheralchemoreflexintheearlystagesofventilatoryacclimatizationtoaltitude |