Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.
The effects of galanin and somatostatin on insulin release, membrane potential, and cytoplasmic free Ca2+ concentration [( Ca2+]i) were investigated using beta-cells isolated from obese hyperglycemic mice. Whereas insulin release was measured in a column perifusion system, membrane potential and [Ca...
Main Authors: | Nilsson, T, Arkhammar, P, Rorsman, P, Berggren, P |
---|---|
Format: | Journal article |
Language: | English |
Published: |
1989
|
Similar Items
-
Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.
by: Nilsson, T, et al.
Published: (1988) -
CLONIDINE INHIBITION OF GLUCOSE-STIMULATED INSULIN-RELEASE INVOLVES REDUCTION OF THE CA-2+ CURRENT
by: Rorsman, P, et al.
Published: (1987) -
MEMBRANE-POTENTIAL, TRANSMEMBRANE CA-45 FLUXES, CYTOPLASMIC FREE CA-2+ CONCENTRATION ([CA-2+]I) AND INSULIN RELEASE BY TRANSPLANTABLE RAT INSULINOMA CELLS
by: Flatt, P, et al.
Published: (1988) -
Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
by: Arkhammar, P, et al.
Published: (1990) -
Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture.
by: Flatt, P, et al.
Published: (1988)