Somatic accumulation of GluA1-AMPA receptors leads to selective cognitive impairments in mice

The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (Gria1R/R), expressing the “trafficking compromised”...

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Main Authors: Bannerman, DM, Borchardt, T, Jensen, V, Rozov, A, Haj-Yasein, NN, Burnashev, N, Zamanillo, D, Bus, T, Grube, I, Adelmann, G, Rawlins, JNP, Sprengel, R
格式: Journal article
语言:English
出版: Frontiers 2018